Document Detail

Protective effect of mango (Mangifera indica L.) against UVB-induced skin aging in hairless mice.
MedLine Citation:
PMID:  23458392     Owner:  NLM     Status:  In-Data-Review    
BACKGROUND: Mangifera indica L. (Anacardiaceae) is a medicinal plant whose extracts have been described as an antioxidant with anti-inflammatory and immunomodulatory activities.
PURPOSE: Skin aging is a consequence of chronic sun exposure to the sun and therefore ultraviolet (UV) radiation. Naturally occurring antioxidants are known to reduce skin aging. Therefore, the aim of the present study was to evaluate the protective role of mango extract against UVB-induced skin aging in hairless mice.
METHODS: HR-1 hairless male mice (6 weeks old) were divided into three groups: control (n = 5), UVB-treated vehicle (n = 5), and UVB-treated mango extract (n = 5) groups. UVB-irradiated mice from the mango extract group were orally administered 0.1 ml of water containing 100 mg of mango extract/kg body weight per day. The inhibitory activity of mango extract on wrinkle formation was determined by the analysis of the skin replica, epidermal thickness based on histological examination, and damage to collagen fiber.
RESULTS: The mean length of wrinkles in UVB-treated vehicle group significantly improved after the oral administration of mango extract, which significantly inhibited the increase in epidermal thickness and epidermal hypertrophy (P < 0.05). Furthermore, a marked increase in collagen bundles was observed in the UVB-treated group after the administration of mango extract by Masson's trichrome staining.
CONCLUSION: These results indicate that mango extract showed anti-photoaging activity in UVB-irradiated hairless mice.
Jae Hyoung Song; Eun Young Bae; Goya Choi; Jin Won Hyun; Mi Young Lee; Hye Won Lee; Sungwook Chae
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Photodermatology, photoimmunology & photomedicine     Volume:  29     ISSN:  1600-0781     ISO Abbreviation:  Photodermatol Photoimmunol Photomed     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-03-05     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9013641     Medline TA:  Photodermatol Photoimmunol Photomed     Country:  England    
Other Details:
Languages:  eng     Pagination:  84-9     Citation Subset:  IM    
Copyright Information:
© 2013 John Wiley & Sons A/S.
Aging Research Laboratory, Korea Institute of Oriental Medicine, Daejeon, Korea; Division of Vaccine Research, Center for Infectious Diseases, National Institutes of Health, Osong, Korea.
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