| Protective effect of lemongrass oil against dexamethasone induced hyperlipidemia in rats: possible role of decreased lecithin cholesterol acetyl transferase activity. | |
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MedLine Citation:
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PMID: 21914547 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate the anti-hyperlipidemic activity of lemongrass oil against in dexamethasone induced hyperlipidemia in rats. METHODS: Administration of dexamethasone was given at 10 mg/kg, sc. to the adult rats for 8 d induces hyperlipidemia characterized by marked increase in serum cholesterol and triglyceride levels along with increase in atherogenic index. RESULTS: Lemongrass oil (100 and 200 mg/kg, po.) treatment has showed significant inhibition against dexamethasone hyperlipidemia by maintaining the serum levels of cholesterol, triglycerides and atherogenic index near to the normal levels and the antihyperlipidemic effect of the lemongross oil was comparable with atorvastatin 10 mg/kg, po. The possible mechanism may be associated with decrease in lecithin cholesterol acetyl transferase (LCAT) activity. CONCLUSIONS: These results suggested that Lemon gross oil possess significant anti-hyperlipidemic activity. |
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Authors:
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Vr Santhosh Kumar; Md Naseeruddin Inamdar; Nayeemunnisa; Gl Viswanatha |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Asian Pacific journal of tropical medicine Volume: 4 ISSN: 1995-7645 ISO Abbreviation: Asian Pac J Trop Med Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-09-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101533720 Medline TA: Asian Pac J Trop Med Country: Singapore |
Other Details:
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Languages: eng Pagination: 658-60 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Hainan Medical College. Published by Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Pharmacology, Al-Ameen College of Pharmacy, Hosur Road, Bangalore, India. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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