Document Detail

Protective effect of bactericidal/permeability-increasing protein (rBPI21) in baboon sepsis is related to its antibacterial, not antiendotoxin, properties.
MedLine Citation:
PMID:  10024109     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE AND SUMMARY BACKGROUND DATA: The recombinant fragment of bactericidal/permeability-increasing protein, rBPI21, has potent bactericidal activity against gram-negative bacteria as well as antiendotoxin (lipopolysaccharide [LPS]) action. On the basis of these activities, the authors sought to discover whether rBPI21 would be protective in baboons with live Escherichia coli-induced sepsis and whether the potential protective effects of rBPI21 (together with antibiotics) would be more closely related to its antibacterial or LPS-neutralizing effects.
METHODS: In a prospective, randomized, placebo-controlled subchronic laboratory study, the efficacy of rBPI21 or placebo was studied over 72 hours in chronically instrumented male baboons infused with live E. coli under antibiotic therapy.
RESULTS: Intravenous rBPI21 attenuated sepsis-related organ failure and increased survival significantly. Bacteremia was significantly reduced in the rBPI21 group at 2 hours after the start of the E. coli infusion, whereas circulating LPS was less affected. The in vivo formation of tumor necrosis factor was significantly suppressed by the rBPI21 treatment regimen. Microcirculation and organ function were improved.
CONCLUSIONS: In baboon live E. coli sepsis, the salutary effect of rBPI21 results from a more prevalent antibacterial than antiendotoxin activity.
G Schlag; H Redl; J Davies; P Scannon
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of surgery     Volume:  229     ISSN:  0003-4932     ISO Abbreviation:  Ann. Surg.     Publication Date:  1999 Feb 
Date Detail:
Created Date:  1999-03-22     Completed Date:  1999-03-22     Revised Date:  2012-09-10    
Medline Journal Info:
Nlm Unique ID:  0372354     Medline TA:  Ann Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  262-71     Citation Subset:  AIM; IM    
Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria.
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MeSH Terms
Escherichia coli Infections / prevention & control*
Hemodynamics / drug effects
Lung / drug effects,  physiology
Membrane Proteins / pharmacology*,  therapeutic use
Random Allocation
Sepsis / prevention & control*
Tumor Necrosis Factor-alpha / biosynthesis
Reg. No./Substance:
0/Membrane Proteins; 0/Tumor Necrosis Factor-alpha; 0/endotoxin binding proteins

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