| Protective effect of heat shock protein 72 on contractile function of perfused failing heart. | |
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MedLine Citation:
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PMID: 11406488 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The contribution of heat shock protein 72 (HSP72) to the protection of cardiac function was examined in rats with chronic heat failure (CHF) following coronary artery ligation (CAL). The CAL animals revealed functional deterioration without low cardiac output 2 wk after CAL and with low cardiac output 8 wk after CAL, suggesting that CHF had developed by 8 wk after CAL. The hearts isolated from animals 2 and 8 wk after CAL (2-wk CAL heart and 8-wk CAL heart, respectively) were subjected to hyperthermia (at 42 degrees C) for 15 min, followed by 6-h perfusion (hyperthermia/6-h perfusion). The 2-wk CAL heart showed a 19.0 +/- 3.9% decline in the rate- pressure product (RPP) after hyperthermia/6-h perfusion, similar to the nonoperated control (19.8 +/- 2.9% decline). The production of myocardial HSP72 increased in the 2-wk CAL heart in response to hyperthermia (412.7 +/- 29.5% of each prehyperthermia value). The 8-wk CAL heart showed a reduction in the RPP (45.2 +/- 4.3% decline) after hyperthermia/6-h perfusion, associated with blunting of the production of HSP72 (68.9 +/- 22.6% increase, respectively). The results suggest that functional deterioration of the isolated failing heart may be attributed to a reduction in the production of myocardial HSP72. |
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Authors:
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K Tanonaka; K I Furuhama; H Yoshida; K Kakuta; Y Miyamoto; W Toga; S Takeo |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of physiology. Heart and circulatory physiology Volume: 281 ISSN: 0363-6135 ISO Abbreviation: Am. J. Physiol. Heart Circ. Physiol. Publication Date: 2001 Jul |
Date Detail:
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Created Date: 2001-06-14 Completed Date: 2001-07-26 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100901228 Medline TA: Am J Physiol Heart Circ Physiol Country: United States |
Other Details:
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Languages: eng Pagination: H215-22 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, Tokyo University of Pharmacy and Life Science, 1432 - 1 Horinouchi, Hachioji, Tokyo 192-0392, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cardiac Output, Low / physiopathology* Chronic Disease HSC70 Heat-Shock Proteins HSP70 Heat-Shock Proteins* HSP72 Heat-Shock Proteins Heart / physiopathology Heat-Shock Proteins / biosynthesis, metabolism, physiology* Hemodynamics Hypothermia, Induced Male Myocardial Contraction / physiology* Myocardial Infarction / pathology Myocardium / metabolism Perfusion Rats Rats, Wistar Reference Values |
| Chemical | |
Reg. No./Substance:
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0/HSC70 Heat-Shock Proteins; 0/HSP70 Heat-Shock Proteins; 0/HSP72 Heat-Shock Proteins; 0/Heat-Shock Proteins; 0/Hspa8 protein, rat |
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