| Protective effect of ginseng on cytokine-induced apoptosis in pancreatic beta-cells. | |
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MedLine Citation:
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PMID: 17381103 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of ginseng extracts (GE) and several ginsenosides on cytokine-induced apoptosis were evaluated. In pancreatic beta-cell line MIN6N8 cells, the inhibitory effect of GE was significantly observed at 25-100 microg/mL: an 86-100% decrease of cytoplasmic DNA fragments quantified by an ELISA. The inhibitory effect of red ginseng (RG) extract was greater than that of white ginseng (WG) extract (IC50, 3.633 vs 4.942 microg/mL). Screening of several known ginsenosides, which were present in ginseng extracts at 0.124-1.19% (w/w) by HPLC analysis, revealed that the ginsenosides were responsible for the inhibition of beta-cell apoptosis at 0.1-1.0 microg/mL. The molecular mechanism, by which GE inhibited beta-cell apoptosis, appeared to involve the reduction of nitric oxide (NO) and reactive oxygen species (ROS) production, inhibition on p53/p21 expression, and inhibition on cleavage of caspases and poly(ADP-ribose) polymerase (PARP). This study suggests that ginseng may inhibit cytokine-induced apoptosis in beta-cells and, thus, may contribute via this action to the antidiabetic influence in type 1 diabetes. |
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Authors:
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Hye Young Kim; Kyong Kim |
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Publication Detail:
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Type: Journal Article Date: 2007-03-24 |
Journal Detail:
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Title: Journal of agricultural and food chemistry Volume: 55 ISSN: 0021-8561 ISO Abbreviation: J. Agric. Food Chem. Publication Date: 2007 Apr |
Date Detail:
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Created Date: 2007-04-11 Completed Date: 2007-06-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0374755 Medline TA: J Agric Food Chem Country: United States |
Other Details:
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Languages: eng Pagination: 2816-23 Citation Subset: IM |
Affiliation:
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Food Function Research Division, Korea Food Research Institute, San 46-1 Baekhyun-dong, Bundang-gu, Songnam-si, Kyonggi-do 463-746, Republic of Korea. khyey@kfri.re.kr |
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis / drug effects* Cell Line Cell Line, Tumor Cytokines / pharmacology* Diabetes Mellitus, Type 1 Ginsenosides / pharmacology* Insulinoma Islets of Langerhans / drug effects* Mice Mice, Inbred NOD Panax / chemistry* Pancreatic Neoplasms Plant Extracts / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Cytokines; 0/Ginsenosides; 0/Plant Extracts |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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