| Protective effect of exogenous coenzyme Q against damage by adriamycin in perfused rat liver. | |
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MedLine Citation:
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PMID: 7981650 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have investigated the effect of rat liver perfusion with adriamycin on mitochondrial activities. Although the perfusion treatment per se induces some decline of respiratory activities, adriamycin strongly potentiates this effect; moreover the coenzyme Q9 content of the mitochondrial membrane is significantly lowered by the antibiotic. Coaddition of coenzyme Q10 in the perfusate significantly protects the mitochondria, not only from loss of respiratory activities but also of the endogenous CoQ9 content. Exogenous CoQ10 fails to enhance respiratory activities in control rats, not treated with adriamycin, even though CoQ concentration has been proven not to be kinetically saturating in the respiratory chain under physiological conditions. Thus, the beneficial effect of CoQ10 in the perfusate does not appear to be the result of its role in the respiratory chain but is a consequence of its antioxidant action. |
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Authors:
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V Valls; C Castelluccio; R Fato; M L Genova; C Bovina; G Saez; M Marchetti; G Parenti Castelli; G Lenaz |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biochemistry and molecular biology international Volume: 33 ISSN: 1039-9712 ISO Abbreviation: Biochem. Mol. Biol. Int. Publication Date: 1994 Jul |
Date Detail:
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Created Date: 1995-01-05 Completed Date: 1995-01-05 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9306673 Medline TA: Biochem Mol Biol Int Country: AUSTRALIA |
Other Details:
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Languages: eng Pagination: 633-42 Citation Subset: IM |
Affiliation:
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Dipartimento di Biochimica Giovanni Moruzzi, Università di Bologna, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antioxidants / pharmacology* Doxorubicin / antagonists & inhibitors*, toxicity Electron Transport / drug effects Male Mitochondria, Liver / drug effects*, metabolism Oxygen Consumption / drug effects Perfusion Rats Rats, Wistar Ubiquinone / metabolism, pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 1339-63-5/Ubiquinone; 23214-92-8/Doxorubicin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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