Document Detail

Protective effect of esmolol on myocardial ischemic injury during open heart surgery in children.
MedLine Citation:
PMID:  23384300     Owner:  NLM     Status:  In-Data-Review    
OBJECTIVES: To investigate the efficacy of esmolol in protecting the myocardium from ischemia during pediatric cardiac surgery.
BACKGROUND: Esmolol, an ultra-short acting beta 1-adrenoceptor blocker, reduces myocardial injury in adult cardiac operations. However, this technique is rarely used in pediatric cardiac surgery.
METHODS: Thirty children with ventricular septal defect were randomly allocated to the esmolol group and the control group. Patients received intravenous esmolol (0.05 mg·kg(-1) ·min(-1) after tracheal intubation, 0.3 mg·kg(-1) ·min(-1) during cardiopulmonary bypass (CPB) and 0.03-0.05 mg·kg(-1) ·min(-1) until the end of surgery) or placebo, respectively.
RESULTS: Plasma levels of creatine kinase-MB, cardiac troponin I in the esmolol group 2 min after completion of CPB, at the end of surgery, 4 h after surgery, and the first postoperative day were significantly lower than those in the control group. Values of heart rate 10 min after induction, 2 min before institution of CPB, 2 min after completion of CPB, and at the end of surgery were significantly lower in the esmolol group; however, mean arterial pressure, CPB time, cross-clamp time, and the rate of heart spontaneous rebeating were not statistically different between two groups. Cumulative postoperative dosage of dopamine in the esmolol group (100.1 ± 53.1 mg) was significantly less than that in the control group (171.4 ± 92.1 mg).
CONCLUSIONS: Esmolol can protect the myocardium from ischemic injury during CPB in children and significantly reduce the use of inotropic drug.
Ping Gui; Qingping Wu; Jing Wu; Shanglong Yao
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Paediatric anaesthesia     Volume:  23     ISSN:  1460-9592     ISO Abbreviation:  Paediatr Anaesth     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-06     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9206575     Medline TA:  Paediatr Anaesth     Country:  France    
Other Details:
Languages:  eng     Pagination:  217-21     Citation Subset:  IM    
Copyright Information:
© 2013 Blackwell Publishing Ltd.
Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Ulinastatin as a neuroprotective and anti-inflammatory agent in infant piglets model undergoing surg...
Next Document:  Modular architecture of metabolic pathways revealed by conserved sequences of reactions.