| Protective effect of esmolol on myocardial ischemic injury during open heart surgery in children. | |
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MedLine Citation:
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PMID: 23384300 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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OBJECTIVES: To investigate the efficacy of esmolol in protecting the myocardium from ischemia during pediatric cardiac surgery. BACKGROUND: Esmolol, an ultra-short acting beta 1-adrenoceptor blocker, reduces myocardial injury in adult cardiac operations. However, this technique is rarely used in pediatric cardiac surgery. METHODS: Thirty children with ventricular septal defect were randomly allocated to the esmolol group and the control group. Patients received intravenous esmolol (0.05 mg·kg(-1) ·min(-1) after tracheal intubation, 0.3 mg·kg(-1) ·min(-1) during cardiopulmonary bypass (CPB) and 0.03-0.05 mg·kg(-1) ·min(-1) until the end of surgery) or placebo, respectively. RESULTS: Plasma levels of creatine kinase-MB, cardiac troponin I in the esmolol group 2 min after completion of CPB, at the end of surgery, 4 h after surgery, and the first postoperative day were significantly lower than those in the control group. Values of heart rate 10 min after induction, 2 min before institution of CPB, 2 min after completion of CPB, and at the end of surgery were significantly lower in the esmolol group; however, mean arterial pressure, CPB time, cross-clamp time, and the rate of heart spontaneous rebeating were not statistically different between two groups. Cumulative postoperative dosage of dopamine in the esmolol group (100.1 ± 53.1 mg) was significantly less than that in the control group (171.4 ± 92.1 mg). CONCLUSIONS: Esmolol can protect the myocardium from ischemic injury during CPB in children and significantly reduce the use of inotropic drug. |
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Authors:
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Ping Gui; Qingping Wu; Jing Wu; Shanglong Yao |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Paediatric anaesthesia Volume: 23 ISSN: 1460-9592 ISO Abbreviation: Paediatr Anaesth Publication Date: 2013 Mar |
Date Detail:
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Created Date: 2013-02-06 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9206575 Medline TA: Paediatr Anaesth Country: France |
Other Details:
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Languages: eng Pagination: 217-21 Citation Subset: IM |
Copyright Information:
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© 2013 Blackwell Publishing Ltd. |
Affiliation:
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Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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