Document Detail


Protective effect of diphenylmethyl selenocyanate against CCl4-induced hepatic injury.
MedLine Citation:
PMID:  17351915     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Organoselenocyanates represent an important class of chemopreventive agent, which possess antioxidative, antimutagenic as well as cancer chemopreventive properties. The present study is an attempt to evaluate the protective effect of diphenylmethyl selenocyanate -- a synthetic organoselenocyanate against carbon tetrachloride (CCl(4))-induced hepatic damage in Swiss albino mice in vivo. Mice were pretreated with the Se-compound orally in a duration dependent manner (7 and 15 days) to observe its protective action against an acute toxic dose (24 h) of CCl(4) (single injection at a dose of 20 microl and 50 microl kg(-1) b.w.) that induced hepatic necrosis and caused DNA damage (strand breaks) in the hepatocytes. This study revealed that pretreatment with the Se-compound reduced the extent of massive hepatic necrosis in a duration dependent manner, but it had no modulatory effect on hepatocellular apoptosis caused by acute toxic doses of CCl(4). It was also found that the Se-compound could significantly (P < 0.01) prevent the CCl(4)-induced elevation of DNA damage in hepatocytes measured by comet assay in a duration dependent manner. So these findings will further strengthen the view that organoselenocyanate is an effective chemopreventive agent against acute hepatic damage, caused by halogenated alkanes such as CCl(4).
Authors:
Rajat Kumar Das; Sk Ugir Hossain; Sudin Bhattacharya
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of applied toxicology : JAT     Volume:  27     ISSN:  0260-437X     ISO Abbreviation:  J Appl Toxicol     Publication Date:    2007 Nov-Dec
Date Detail:
Created Date:  2007-10-30     Completed Date:  2007-12-13     Revised Date:  2009-11-03    
Medline Journal Info:
Nlm Unique ID:  8109495     Medline TA:  J Appl Toxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  527-37     Citation Subset:  IM    
Affiliation:
Department of Cancer Chemoprevention, Chittaranjan National Cancer Institute, Kolkata, India.
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Animals
Antioxidants / administration & dosage,  pharmacology*,  therapeutic use
Apoptosis / drug effects
Carbon Tetrachloride
Comet Assay
DNA Damage / drug effects*
Disease Models, Animal
Female
Liver / drug effects*,  metabolism,  pathology
Massive Hepatic Necrosis / chemically induced,  metabolism,  pathology,  prevention & control*
Mice
Organoselenium Compounds / administration & dosage,  pharmacology*,  therapeutic use
Oxidative Stress / drug effects
Time Factors
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Organoselenium Compounds; 0/diphenylmethyl selenocyanate; 56-23-5/Carbon Tetrachloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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