Document Detail


Protective effect of dietary brussels sprouts against mammary carcinogenesis in Sprague-Dawley rats.
MedLine Citation:
PMID:  3129179     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of dietary brussels sprouts (Brassica oleracea, L.) on mammary carcinogenesis induced by 7,12-dimethylbenz[a]anthracene (DMBA) was studied in Sprague-Dawley female rats. Rats fed a 20% brussels sprouts diet only during the initiation period of carcinogenesis had a palpable mammary tumor incidence of 13%, while those fed a casein-cornstarch semi-purified diet during this initiation period had a tumor incidence of 77% after 15 weeks post DMBA dose. When the rats were switched from the semi-purified diet to the 20% brussels sprouts diet at this time, there appeared to be a regression of small mammary tumors after 6 weeks on this dietary treatment. This regression was transitory since during the final 10 weeks of this 1 year study, 100% of this group of rats developed tumors. The rats fed the 20% brussels sprouts diet during tumor initiation exhibited a 67% incidence of fibroadenomas. The rats fed the semi-purified diet during initiation, but switched later to the brussels sprouts diet, showed over a 90% incidence of adenocarcinomas.
Authors:
G S Stoewsand; J L Anderson; L Munson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cancer letters     Volume:  39     ISSN:  0304-3835     ISO Abbreviation:  Cancer Lett.     Publication Date:  1988 Mar 
Date Detail:
Created Date:  1988-06-02     Completed Date:  1988-06-02     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7600053     Medline TA:  Cancer Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  199-207     Citation Subset:  IM    
Affiliation:
Department of Food Science and Technology, Cornell University, Geneva, NY 14456.
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MeSH Terms
Descriptor/Qualifier:
9,10-Dimethyl-1,2-benzanthracene
Animals
Body Weight
Brassica* / analysis
Diet
Female
Glucosinolates / analysis
Mammary Neoplasms, Experimental / prevention & control*
Rats
Rats, Inbred Strains
Chemical
Reg. No./Substance:
0/Glucosinolates; 57-97-6/9,10-Dimethyl-1,2-benzanthracene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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