Document Detail

Protective effect of carvedilol on adriamycin-induced left ventricular dysfunction in children with acute lymphoblastic leukemia.
MedLine Citation:
PMID:  22858075     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Adriamycin (ADR) is a potent chemotherapeutic agent widely used in the treatment of childhood acute lymphoblastic leukemia (ALL); its clinical use is limited owing to its marked cardiotoxicity. The present study investigated the possible protective role of carvedilol on ADR-induced left ventricular dysfunction in children with ALL.
METHODS AND RESULTS: Fifty children with newly diagnosed ALL were included in this study. They were divided into 2 equal groups: 1) ADR; and 2) ADR + carvedilol. Patients were evaluated with conventional 2-dimensional echocardiographic examination (2D), pulsed tissue Doppler (PTD), and 2-dimensional longitudinal strain echocardiography (2DS) before and after therapy. Plasma lactic dehydrogenase (LDH), creatine phosphokinase (CPK), and troponin I levels were also determined before and after therapy. ADR treatment reduced left ventricular systolic dysfunction as assessed by a significant decrease in fractional shortening (FS) (2D) and global peak-systolic strain (GPSS; 2DS). In addition, ADR treatment significantly increased plasma troponin I and LDH. Pretreatment of ADR-treated patients with carvedilol resulted in a significant increase in FS (2D) and GPSS (2DS). Furthermore, carvedilol pretreatment inhibited ADR-induced increase in plasma troponin I and LDH.
CONCLUSIONS: These results suggested a protective role of carvedilol against ADR-induced cardiotoxicity.
Nagla A El-Shitany; Osama A Tolba; Mohamed R El-Shanshory; Eslam E El-Hawary
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of cardiac failure     Volume:  18     ISSN:  1532-8414     ISO Abbreviation:  J. Card. Fail.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-08-03     Completed Date:  2012-12-17     Revised Date:  2013-05-28    
Medline Journal Info:
Nlm Unique ID:  9442138     Medline TA:  J Card Fail     Country:  United States    
Other Details:
Languages:  eng     Pagination:  607-13     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Department of Pharmacology and Toxicology, College of Pharmacy, Tanta University, Tanta, Egypt.
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MeSH Terms
Antibiotics, Antineoplastic / adverse effects*
Carbazoles / pharmacology,  therapeutic use*
Child Welfare
Doxorubicin / adverse effects*
Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy,  pathology*
Propanolamines / pharmacology,  therapeutic use*
Time Factors
Vasodilator Agents / pharmacology,  therapeutic use*
Ventricular Dysfunction, Left / chemically induced*,  pathology,  ultrasonography
Reg. No./Substance:
0/Antibiotics, Antineoplastic; 0/Carbazoles; 0/Propanolamines; 0/Vasodilator Agents; 0K47UL67F2/carvedilol; 23214-92-8/Doxorubicin

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