Document Detail


Protective effect of carnosine on Cu,Zn-superoxide dismutase during impaired oxidative metabolism in the brain in vivo.
MedLine Citation:
PMID:  12802415     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Natural hydrophilic antioxidant carnosine protects cerebral cytosolic Cu,Zn-superoxide dismutase (SOD) under conditions of oxidative stress in various in vivo models: short-term hypobaric hypoxia in rats and accumulation of age-related changes in senescence-accelerated mice (SAMP). Administration of carnosine preventing Cu,Zn-SOD inactivation reduced mortality in rats and prolonged average life span in SAMP-mice.
Authors:
S L Stvolinskii; T N Fedorova; M O Yuneva; A A Boldyrev
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Bulletin of experimental biology and medicine     Volume:  135     ISSN:  0007-4888     ISO Abbreviation:  Bull. Exp. Biol. Med.     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-06-12     Completed Date:  2004-05-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372557     Medline TA:  Bull Exp Biol Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  130-2     Citation Subset:  IM    
Affiliation:
Institute of Neurology, Russian Academy of Medical Sciences, Moscow. sls@bio.inevro.msk.ru
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MeSH Terms
Descriptor/Qualifier:
Aging, Premature / metabolism
Animals
Anoxia / metabolism
Antioxidants / administration & dosage,  pharmacology*
Brain / metabolism*
Carnosine / administration & dosage,  pharmacology*
Lipid Peroxidation
Male
Mice
Oxidative Stress*
Rats
Rats, Wistar
Superoxide Dismutase / metabolism*
Chemical
Reg. No./Substance:
0/Antioxidants; 305-84-0/Carnosine; EC 1.15.1.1/Superoxide Dismutase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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