| Protective effect of carbidopa on hydroxyl radical generation in the rat striatum by dopamine. | |
| | |
MedLine Citation:
|
PMID: 9014169 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The effect of L-3,4-dihydroxyphenylalanine (L-DOPA) on the generation of hydroxyl free radicals (.OH) was investigated using striatal microdialysis technique. Salicylic acid in Ringer's solution (0.5 nmol.microliters-1.min-1) was infused directly through a microdialysis probe to detect the generation of .OH as reflected by the formation of dihydroxybenzoic acids (DHBA) in the striatum. When L-DOPA (0.1 mM; 1 microliter.min-1) was infused in the rat brain, the level of 3,4-dihydroxyphenylacetic acid (DOPAC) gradually increased in a time-dependent manner. In addition, a marked elevation of DHBA was observed. However, in the presence of carbidopa, a decarboxylase inhibitor, the elevation in DHBA formation was not observed. These results suggest that carbidopa may suppress the .OH generation by dopamine (DA). |
| | |
Authors:
|
T Obata; Y Yamanaka |
Related Documents
:
|
1185179 - Viability of some metabolic processes in the isolated toad brain adapted to two osmotic... 2594149 - Changes of amino acid gradients in brain tissues induced by microwave irradiation and o... 1295669 - Anoxia-induced extracellular ionic changes in cns white matter: the role of glial cells. 6148379 - Amino acid transport by synaptosomes isolated from post mortem human brain. 11571699 - Phenotypic heterogeneity and adverse effects of serine treatment in 3-phosphoglycerate ... 2865779 - Excitatory and inhibitory amino acid neurotransmitters and ammonia metabolism in hepati... 1194469 - Growth and carcass evaluation of holstein steers fed liquid acid whey. 8225229 - Selectivity and sensitivity of changes in serum bile acids during induction of cirrhosi... 7617759 - Antiulcer action and toxicity of styrax camporum and caesalpinia ferrea. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Neuroscience letters Volume: 221 ISSN: 0304-3940 ISO Abbreviation: Neurosci. Lett. Publication Date: 1996 Dec |
Date Detail:
|
Created Date: 1997-04-09 Completed Date: 1997-04-09 Revised Date: 2003-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: IRELAND |
Other Details:
|
Languages: eng Pagination: 13-6 Citation Subset: IM |
Affiliation:
|
Department of Pharmacology, Oita Medical University, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
3,4-Dihydroxyphenylacetic Acid
/
metabolism Animals Carbidopa / pharmacology* Chromatography, High Pressure Liquid Cyclooxygenase Inhibitors / pharmacology Dopamine / metabolism* Dopamine Agents / pharmacology* Free Radicals / metabolism Hydroxides Levodopa / pharmacology Male Microdialysis Neostriatum / drug effects, metabolism* Neuroprotective Agents / pharmacology Rats Rats, Wistar Sodium Salicylate / pharmacology |
| Chemical | |
Reg. No./Substance:
|
0/Cyclooxygenase Inhibitors; 0/Dopamine Agents; 0/Free Radicals; 0/Hydroxides; 0/Levodopa; 0/Neuroprotective Agents; 102-32-9/3,4-Dihydroxyphenylacetic Acid; 14280-30-9/hydroxide ion; 38821-49-7/Carbidopa; 54-21-7/Sodium Salicylate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Tetrodotoxin-resistant Na+ spikes of C fibers have at least two subtypes in the isolated bullfrog sc...
Next Document: Immunohistochemical study of advanced glycation end products in aging and Alzheimer's disease brain.