| Protective effect of binaphthyl diselenide, a synthetic organoselenium compound, on 2-nitropropane-induced hepatotoxicity in rats. | |
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MedLine Citation:
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PMID: 20517888 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Organoselenides have been documented as promising pharmacological agents against a number of diseases associated with oxidative stress. Here we have investigated, for the first time, the potential antioxidant activity of binaphthyl diselenide ((NapSe)(2); 50 mg kg(-1), p.o.) against the 2-nitropropane (2-NP)-induced hepatoxicity in rats, using different end points of toxicity (liver histopathology, plasma aspartate aminotransferase (AST), alanine aminotransferase (ALT) and creatinine). In addition, in view of the association of oxidative stress with 2-NP exposure, hepatic lipid peroxidation, ascorbic acid levels, delta-aminolevulinate dehydratase (delta-ALA-D) and catalase (CAT) activities were evaluated. 2-NP caused an increase of AST, ALT and hepatic lipid peroxidation. 2-NP also caused hepatic histopathological alterations and delta-ALA-D inhibition. (NapSe)(2) (50 mg kg(-1)) prevented 2-NP-induced changes in plasmatic ALT and AST activities and also prevented changes in hepatic histology, delta-ALA-D and lipid peroxidation. Results presented here indicate that the protective mechanism of (NapSe)(2) against 2-NP hepatotoxicity is possibly linked to its antioxidant activity. |
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Authors:
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Mohammad Ibrahim; Marina Prigol; Waseem Hassan; Cristina W Nogueira; Joao B T Rocha |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Cell biochemistry and function Volume: 28 ISSN: 1099-0844 ISO Abbreviation: Cell Biochem. Funct. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-02 Completed Date: 2010-09-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8305874 Medline TA: Cell Biochem Funct Country: England |
Other Details:
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Languages: eng Pagination: 258-65 Citation Subset: IM |
Copyright Information:
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2010 John Wiley & Sons, Ltd. |
Affiliation:
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Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alanine Transaminase
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metabolism Animals Antioxidants / chemistry, pharmacology* Ascorbic Acid / metabolism Aspartate Aminotransferases / metabolism Catalase / metabolism Creatinine / metabolism Drug-Induced Liver Injury / pathology, prevention & control* Lipid Peroxidation Nitroparaffins / toxicity Organoselenium Compounds / chemistry, pharmacology* Oxidative Stress Porphobilinogen Synthase / metabolism Propane / analogs & derivatives, toxicity Rats |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Nitroparaffins; 0/Organoselenium Compounds; 0/binaphthyl diselenide; 50-81-7/Ascorbic Acid; 60-27-5/Creatinine; 74-98-6/Propane; 79-46-9/2-nitropropane; EC 1.11.1.6/Catalase; EC 2.6.1.1/Aspartate Aminotransferases; EC 2.6.1.2/Alanine Transaminase; EC 4.2.1.24/Porphobilinogen Synthase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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