Document Detail

Protective effect of bile acids on the onset of fructose-induced hepatic steatosis in mice.
MedLine Citation:
PMID:  20847296     Owner:  NLM     Status:  MEDLINE    
Fructose intake is being discussed as a key dietary factor in the development of nonalcoholic fatty liver disease (NAFLD). Bile acids have been shown to modulate energy metabolism. We tested the effects of bile acids on fructose-induced hepatic steatosis. In C57BL/6J mice treated with a combination of chenodeoxycholic acid and cholic acid (100 mg/kg body weight each) while drinking water or a 30% fructose solution for eight weeks and appropriate controls, markers of hepatic steatosis, portal endotoxin levels, and markers of hepatic lipogenesis were determined. In mice concomitantly treated with bile acids, the onset of fructose-induced hepatic steatosis was markedly attenuated compared to mice only fed fructose. The protective effects of the bile acid treatment were associated with a downregulation of tumor necrosis factor (TNF)α, sterol regulatory element-binding protein (SREBP)1, FAS mRNA expression, and lipid peroxidation in the liver, whereas hepatic farnesoid X receptor (FXR) or short heterodimer partner (SHP) protein concentration did not differ between groups fed fructose. Rather, bile acid treatment normalized occludin protein concentration in the duodenum, portal endotoxin levels, and markers of Kupffer cell activation to the level of water controls. Taken together, these data suggest that bile acids prevent fructose-induced hepatic steatosis in mice through mechanisms involving protection against the fructose-induced translocation of intestinal bacterial endotoxin.
Valentina Volynets; Astrid Spruss; Giridhar Kanuri; Sabine Wagnerberger; Stephan C Bischoff; Ina Bergheim
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-09-16
Journal Detail:
Title:  Journal of lipid research     Volume:  51     ISSN:  0022-2275     ISO Abbreviation:  J. Lipid Res.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-10     Completed Date:  2011-02-22     Revised Date:  2013-05-27    
Medline Journal Info:
Nlm Unique ID:  0376606     Medline TA:  J Lipid Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3414-24     Citation Subset:  IM    
Department of Nutritional Medicine, University of Hohenheim, Stuttgart, Germany.
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MeSH Terms
Bile Acids and Salts / metabolism*
Dietary Sucrose / metabolism*
Duodenum / metabolism
Endotoxins / metabolism
Fatty Liver / chemically induced*,  metabolism*,  pathology
Fructose / metabolism*
Gene Expression Regulation
Lipid Peroxidation / drug effects
Membrane Proteins / metabolism
Mice, Inbred C57BL
RNA, Messenger / metabolism
Receptors, Cytoplasmic and Nuclear / metabolism
Sterol Regulatory Element Binding Protein 1 / metabolism
Tumor Necrosis Factor-alpha / metabolism
Reg. No./Substance:
0/Bile Acids and Salts; 0/Dietary Sucrose; 0/Endotoxins; 0/Membrane Proteins; 0/Occludin; 0/Ocln protein, mouse; 0/RNA, Messenger; 0/Receptors, Cytoplasmic and Nuclear; 0/Sterol Regulatory Element Binding Protein 1; 0/Tumor Necrosis Factor-alpha; 0/farnesoid X-activated receptor; 30237-26-4/Fructose

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