Document Detail

Protective effect of anisodamine on respiratory function after severe brain injury.
MedLine Citation:
PMID:  12443576     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To study the clinical therapeutic effect of anisodamine on respiratory function after severe brain injury. METHODS: Ninety patients with respiratory dysfunction following severe brain injury were divided into two groups: a treatment group (n = 45, treated with routine therapy plus anisodamine) and a control group (n = 45, treated with routine therapy only). The pulmonary ventilation function and oxygenation function were compared between the two groups. RESULTS: In the treatment group, 12 hours after treatment the respiratory rate reduced, the partial pressure of carbon dioxide (PCO(2)), the partial pressure of oxygen in arterial blood (PaO(2)) and oxygenation exponent increased, the dead space ventilation dose and the pulmonary alveolus-partial pressure of arterial oxygen difference decreased, and the ventilation function of the respiratory tract and pulmonary oxygenation function improved. There was a significant difference between the two groups (P < 0.01). No side-effect was found except a slight increase of intracranial pressure and heart rate. CONCLUSIONS: Anisodamine can improve pulmonary ventilation function and oxygenation function and decrease the incidence of hypoxemia markedly. It is effective in treating respiratory dysfunction after severe brain injury.
Qiang Huang; Weimin Dai; Yuanqing Jie; Guofeng Yu
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Chinese journal of traumatology = Zhonghua chuang shang za zhi / Chinese Medical Association     Volume:  5     ISSN:  1008-1275     ISO Abbreviation:  Chin. J. Traumatol.     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2002-11-21     Completed Date:  2003-03-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100886162     Medline TA:  Chin J Traumatol     Country:  China    
Other Details:
Languages:  eng     Pagination:  352-4     Citation Subset:  IM    
Neurosurgery Department, People's Hospital of Quzhou City, Quzhou 324000, China.
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MeSH Terms
Brain Injuries / complications*,  diagnosis,  mortality
Dose-Response Relationship, Drug
Drug Administration Schedule
Follow-Up Studies
Infusions, Intravenous
Injury Severity Score
Middle Aged
Primary Prevention / methods
Pulmonary Gas Exchange
Reference Values
Respiratory Function Tests
Respiratory Insufficiency / etiology,  mortality,  prevention & control*
Solanaceous Alkaloids / administration & dosage*
Survival Rate
Treatment Outcome
Reg. No./Substance:
0/Solanaceous Alkaloids; 55869-99-3/anisodamine

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