| Protective effect of angiotensin converting enzyme inhibitors (CEI): captopril and perindopril on vulnerability to ventricular fibrillation during myocardial ischemia and reperfusion in rat. | |
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MedLine Citation:
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PMID: 3038396 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of the present study was to evaluate the effects of two CEI: captopril and perindopril on reperfusion arrhythmias and noradrenaline 3H (NA3H) release in the isolated rat heart on arrhythmias in pentobarbitone anaesthetized rats subject to left coronary artery ligation. In vitro, in control preparations, reperfusion after 10 min of local ischemia produced by coronary ligation was accompanied by a sudden release of NA3H in coronary flow and long lasting ventricular arrhythmias. Reperfusion arrhythmias were prevented by perfusion medium containing a high dose of CEI and CEI did not change the patterns of NA3H release. In vivo, mortality due to ventricular fibrillation was significantly reduced in rats pretreated with captopril or perindopril 15 min prior to coronary ligation. CEI reduced the severity of ventricular tachycardia (VT) and fibrillation (VF). |
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Authors:
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L Rochette; C Ribuot; P Belichard; A Bril; M Devissaguet |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: Clinical and experimental hypertension. Part A, Theory and practice Volume: 9 ISSN: 0730-0077 ISO Abbreviation: Clin Exp Hypertens A Publication Date: 1987 |
Date Detail:
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Created Date: 1987-08-28 Completed Date: 1987-08-28 Revised Date: 2008-02-12 |
Medline Journal Info:
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Nlm Unique ID: 8207790 Medline TA: Clin Exp Hypertens A Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 365-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angiotensin-Converting Enzyme Inhibitors* Animals Captopril / therapeutic use* Coronary Circulation / drug effects Coronary Disease / complications* Heart Rate / drug effects Indoles / therapeutic use* Male Norepinephrine / pharmacology Perindopril Rats Ventricular Fibrillation / etiology, prevention & control* |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin-Converting Enzyme Inhibitors; 0/Indoles; 51-41-2/Norepinephrine; 62571-86-2/Captopril; 82834-16-0/Perindopril |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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