Document Detail


Protective effect of Solanum torvum on doxorubicin-induced nephrotoxicity in rats.
MedLine Citation:
PMID:  19883716     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Nephrotoxicity is one of the important side effects of anthracycline antibiotics. The aim of the study was to determine the protective effect of Solanum torvum on doxorubicin-induced nephrotoxicity in rats using biochemical and histopathological approaches. Oxidative stress is the main factor in doxorubicin (DOX) induced nephrotoxicity. Wistar rats received either DOX (67.75 mg/kg, i.v, 2 days before sacrifice) or S. torvum (100mg/kg and 300 mg/kg, p.o.) prior to DOX treatment or S. torvum (100mg/kg and 300 mg/kg, p.o.) extract alone for 4 weeks. Nephrotoxicity was assessed by measuring the abnormal levels of serum creatinine and blood urea nitrogen (BUN). The anti-oxidant defence enzymes superoxide dismutase (SOD) and catalase (CAT) of kidney tissue were also measured at the end of the treatment schedule. Treatment with S. torvum (100mg/kg and 300 mg/kg) significantly (p<0.05) decreased the levels of creatinine and BUN and significantly (p<0.05) increased the anti-oxidant defence enzyme levels of SOD and CAT. Histopathological changes showed that DOX caused significant structural damages to kidneys like tubular necrosis, renal lesions and glomerular congestion which was reversed with S. torvum. The results suggest that S. torvum has the potential in preventing the nephrotoxicity induced by doxorubicin.
Authors:
Mahalaxmi Mohan; Sarika Kamble; Prakash Gadhi; Sanjay Kasture
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Publication Detail:
Type:  Journal Article     Date:  2009-10-31
Journal Detail:
Title:  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association     Volume:  48     ISSN:  1873-6351     ISO Abbreviation:  Food Chem. Toxicol.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-02-01     Completed Date:  2010-04-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8207483     Medline TA:  Food Chem Toxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  436-40     Citation Subset:  IM    
Copyright Information:
Copyright 2009 Elsevier Ltd. All rights reserved.
Affiliation:
Department of Pharmacology, MGV's Pharmacy College, Panchavati, Nashik 422 003, Maharashtra, India. mm_nasik@yahoo.co.in
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MeSH Terms
Descriptor/Qualifier:
Animals
Antibiotics, Antineoplastic / antagonists & inhibitors*,  toxicity*
Antioxidants / pharmacology
Blood Urea Nitrogen
Catalase / metabolism
Creatinine / blood
Doxorubicin / antagonists & inhibitors*,  toxicity*
Female
Kidney / enzymology
Kidney Diseases / chemically induced*,  prevention & control*
Male
Plant Extracts / pharmacology
Rats
Rats, Wistar
Solanum / chemistry*
Superoxide Dismutase / metabolism
Chemical
Reg. No./Substance:
0/Antibiotics, Antineoplastic; 0/Antioxidants; 0/Plant Extracts; 23214-92-8/Doxorubicin; 60-27-5/Creatinine; EC 1.11.1.6/Catalase; EC 1.15.1.1/Superoxide Dismutase

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