| Protective effect of Smilax glabra extract against lead-induced oxidative stress in rats. | |
| | |
MedLine Citation:
|
PMID: 20580805 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
ETHNOPHARMACOLOGICAL RELEVANCE: Smilax glabra Roxb. is a traditional Chinese herb, the rhizome of Smilax glabra has been used in folk medicine for the treatment of lead poisoning. AIMS OF THE STUDY: The present study was conducted to investigate the protective role of Smilax glabra extract (SGE) individually or combined with meso-2,3-dimercaptosuccinic acid (DMSA) against the effects of lead acetate on oxidative stress and lead burden in rats. MATERIALS AND METHODS: The biochemical parameters and enzymes in different treated rats were determined by commercial kits. The metal concentrations were measured using atomic absorption spectrophotometer. RESULTS: SGE (300 mg/kg) showed very low toxicity to organs in non-lead exposed rats. Administration of SGE individually had no effect on blood zinc protoporphyrin (ZPP) level but significantly enhanced the glutathione (GSH) content and delta-aminolevulinic acid dehydratase (ALAD), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) activities in lead exposed rats. The co-treatment of SGE and DMSA had a synergism in increasing brain, liver and kidney superoxide dismutase (SOD), catalase (CAT) activities and GSH level, and decreasing oxidized glutathione (GSSG) and thiobarbituric acid reactive substances (TBARS) levels. Moreover, the co-treatment could improve the hepatic and renal histopathology changes. SGE as chelating agent showed significant efficiency in reducing blood and tissue lead burden. CONCLUSIONS: The in vivo results suggested that SGE individually or combined with DMSA exhibited remarkable protective effects on lead-induced oxidative stress and lead burden in rats. |
| | |
Authors:
|
Daozong Xia; Xinfen Yu; Sipei Liao; Qijia Shao; Huili Mou; Wei Ma |
Related Documents
:
|
508895 - Porphobilinogen synthetase activity response to increased levels of reduced glutathione... 6873245 - The effect of propylthiouracil on glutathione s-transferase activity of rat spleen in v... 2513085 - Regional effects of 6-hydroxydopamine (6-ohda) on free radical scavengers in rat brain. 10356275 - Use of in vitro data for construction of a physiologically based pharmacokinetic model ... 12727475 - Oncogene expression on the syngeneic beta-cells of long-term surviving pancreatic graft... 7539535 - Corticosterone increases na(+)-k(+)-atpase activity in rat cortical collecting ducts wi... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-05-24 |
Journal Detail:
|
Title: Journal of ethnopharmacology Volume: 130 ISSN: 1872-7573 ISO Abbreviation: J Ethnopharmacol Publication Date: 2010 Jul |
Date Detail:
|
Created Date: 2010-07-20 Completed Date: 2010-11-04 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7903310 Medline TA: J Ethnopharmacol Country: Ireland |
Other Details:
|
Languages: eng Pagination: 414-20 Citation Subset: IM |
Copyright Information:
|
Copyright 2010 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
|
College of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Binjiang District, Hangzhou, China. xdz_zjtcm@hotmail.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Alanine Transaminase
/
blood Alkaline Phosphatase / blood Animals Antidotes / pharmacology Antioxidants / pharmacology* Body Burden Brain / drug effects, metabolism Catalase / metabolism Chelating Agents / pharmacology Disease Models, Animal Flavonoids / analysis Glutathione / blood Kidney / drug effects, metabolism Lead Poisoning / drug therapy*, etiology, metabolism Liver / drug effects, metabolism Male Organometallic Compounds / blood Oxidative Stress / drug effects* Phenols / analysis Plant Extracts / chemistry, pharmacology* Porphobilinogen Synthase / blood Protoporphyrins / blood Rats Rats, Wistar Rhizome Smilax* Succimer / pharmacology Superoxide Dismutase / metabolism Thiobarbituric Acid Reactive Substances / metabolism |
| Chemical | |
Reg. No./Substance:
|
0/Antidotes; 0/Antioxidants; 0/Chelating Agents; 0/Flavonoids; 0/Organometallic Compounds; 0/Phenols; 0/Plant Extracts; 0/Protoporphyrins; 0/Thiobarbituric Acid Reactive Substances; 15442-64-5/zinc protoporphyrin; 301-04-2/lead acetate; 304-55-2/Succimer; 70-18-8/Glutathione; EC 1.11.1.6/Catalase; EC 1.15.1.1/Superoxide Dismutase; EC 2.6.1.2/Alanine Transaminase; EC 3.1.3.1/Alkaline Phosphatase; EC 4.2.1.24/Porphobilinogen Synthase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Pharmacokinetic properties of paeoniflorin, albiflorin and oxypaeoniflorin after oral gavage of extr...
Next Document: Alteration of lipid metabolism in cells infected with human cytomegalovirus.