Document Detail

Protective effect of N-acetylcysteine in isoniazid induced hepatic injury in growing rats.
MedLine Citation:
PMID:  11510126     Owner:  NLM     Status:  MEDLINE    
Status of oxidative/antioxidative profile was the mechanistic approach to inumerate the nature of protection by N-acetylcysteine (NAC) in isoniazid (INH) exposed experimental animals. Analysis of lipid peroxidation, thiol levels, cytochrome P450, superoxide dismutase (SOD), catalase, glutathione peroxidase, reductase and transferase were estimated in liver along with the body and liver weight of animals and histological observations. Isoniazid exposure to animals resulted in no change in body and liver weights. Thiols, lipid peroxidation, catalase, SOD glutathione peroxidase, reductase, transferase and cytochrome P450 levels were altered with INH exposure. Supplementation of NAC with INH protected the animals against hepatotoxic reactions by minimizing the free radical induced tissue injury and overall maintenance of the endogenous scavengers of free radicals.
S Attri; S V Rana; K Vaiphie; R Katyal; C P Sodhi; S Kanwar; K Singh
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Indian journal of experimental biology     Volume:  39     ISSN:  0019-5189     ISO Abbreviation:  Indian J. Exp. Biol.     Publication Date:  2001 May 
Date Detail:
Created Date:  2001-08-20     Completed Date:  2001-10-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0233411     Medline TA:  Indian J Exp Biol     Country:  India    
Other Details:
Languages:  eng     Pagination:  436-40     Citation Subset:  IM    
Department of Biochemistry, Govt. Medical College, Chandigarh 160 032, India.
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MeSH Terms
Acetylcysteine / pharmacology*
Antioxidants / metabolism
Free Radical Scavengers / metabolism
Glutathione / metabolism
Isoniazid / antagonists & inhibitors*,  toxicity
Liver / drug effects*,  injuries,  metabolism,  pathology
Oxidants / toxicity
Rats, Wistar
Reg. No./Substance:
0/Antioxidants; 0/Free Radical Scavengers; 0/Oxidants; 54-85-3/Isoniazid; 616-91-1/Acetylcysteine; 70-18-8/Glutathione

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