| Protective effect of Morus rubra L. leaf extract on diet-induced atherosclerosis in diabetic rats. | |
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MedLine Citation:
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PMID: 21086751 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The antiatherosclerotic effect of aqueous leaves extract of Morus rubra was studied in streptozotocin-induced diabetic rats fed with atherosclerotic (Ath) diet [1.5 ml olive oil containing 8 mg (3, 20,000 IU) vitamin D2 and 40 mg cholesterol] for 5 consecutive days. A short-term toxicity assessment was also conducted in healthy rats to examine toxic effects of the extract. Oral administration of extract to diabetic rats (100, 200 and 400 mg/kg body weight per day for a period of 30 days) produced significant (p<0.001) fall in fasting blood glucose (FBG) in a dose-dependent manner. Treatment with the extract (400 mg/kg) showed significant (p<0.001) improvement in body weight and serum lipid profile i.e., total cholesterol, triglyceride, HDL-cholesterol, LDL-cholesterol and VLDL-cholesterol, when compared with diabetic control. Endothelial dysfunction parameters (sVCAM-1, Fibrinogen, total NO levels and oxidized LDL), apolipoprotein A and apolipoprotein B were significantly (p<0.001) reversed to near normal, following treatment with the extract. Thus, our study shows that aqueous leaf extract of Morus rubra (400 mg/kg) significantly improves the homeostasis of glucose and fat and possesses significant anti-atherosclerotic activity. |
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Authors:
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Suman Bala Sharma; Reenu Singh Tanwar; A C Rini; Usha Rani Singh; Shipra Gupta; Santosh Kumar Shukla |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Indian journal of biochemistry & biophysics Volume: 47 ISSN: 0301-1208 ISO Abbreviation: Indian J. Biochem. Biophys. Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-11-19 Completed Date: 2010-12-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0310774 Medline TA: Indian J Biochem Biophys Country: India |
Other Details:
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Languages: eng Pagination: 26-31 Citation Subset: IM |
Affiliation:
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Department of Biochemistry, University College of Medical Sciences, University of Delhi, Delhi 110095, India. drsbs08@hotmail.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Atherosclerosis / etiology, prevention & control* Blood Glucose / analysis Dietary Fats / administration & dosage* Morus / chemistry* Plant Extracts / therapeutic use* Plant Leaves / chemistry* Rats Triglycerides / analysis |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Dietary Fats; 0/Plant Extracts; 0/Triglycerides |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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