Document Detail

Protective effect of Acacia confusa bark extract and its active compound gallic acid against carbon tetrachloride-induced chronic liver injury in rats.
MedLine Citation:
PMID:  19327382     Owner:  NLM     Status:  MEDLINE    
Acacia confusa Merr. (Leguminosae), a species native to Taiwan, is widely distributed on the hills and lowlands of Taiwan, and has been traditionally used as a medicine. The hepatoprotective effects of A. confusa bark extract (ACBE) and its active constituent gallic acid were evaluated against carbon tetrachloride (CCl(4))-induced hepatotoxicity in rats. CCl(4)-induced hepatic pathological damage and significantly increased the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and malondialdehyde (MDA) in plasma, and cytochrome P4502E1 (CYP2E1) protein expression in hepatic samples, and decreased the activities of superoxide dismutase (SOD), glutathione peroxidase (GPX) and catalase (CAT) in erythrocytes. Treatment with ACBE, gallic acid or silymarin could decrease significantly the AST, ALT, and MDA levels in plasma, and CYP2E1 expression in liver tissues, and increase the activities of SOD and GPX in erythrocyte when compared with CCl(4)-treated group. Liver histopathology also showed that ACBE, gallic acid or silymarin could significantly reduce the incidence of liver lesions induced by CCl(4). These results suggested that the ACBE and gallic acid exhibit potent hepatoprotection against CCl(4)-induced liver damages in rats, and the hepatoprotective effects of ACBE and gallic acid may be due to the modulation of antioxidant enzymes activities and inhibition of lipid peroxidation and CYP2E1 activation.
Yu-Tang Tung; Jyh-Horng Wu; Chi-Chang Huang; Hsiang-Chi Peng; Ya-Ling Chen; Suh-Ching Yang; Shang-Tzen Chang
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-03-25
Journal Detail:
Title:  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association     Volume:  47     ISSN:  1873-6351     ISO Abbreviation:  Food Chem. Toxicol.     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-05-04     Completed Date:  2009-07-16     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8207483     Medline TA:  Food Chem Toxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1385-92     Citation Subset:  IM    
School of Forestry and Resource Conservation, National Taiwan University, Taipei 106, Taiwan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Acacia / chemistry*
Antioxidants / metabolism
Blotting, Western
Carbon Tetrachloride Poisoning / pathology,  prevention & control*
Cytochrome P-450 CYP2E1 / metabolism
Drug-Induced Liver Injury / pathology,  prevention & control*
Erythrocytes / drug effects,  metabolism
Gallic Acid / pharmacology*
Lipid Peroxidation / drug effects
Liver / pathology
Liver Function Tests
Plant Bark / chemistry
Plant Extracts / pharmacology
Rats, Sprague-Dawley
Thiobarbituric Acid Reactive Substances / metabolism
Reg. No./Substance:
0/Antioxidants; 0/Plant Extracts; 0/Thiobarbituric Acid Reactive Substances; 149-91-7/Gallic Acid; EC P-450 CYP2E1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Protective effects of Digera muricata (L.) Mart. on testis against oxidative stress of carbon tetrac...
Next Document:  Identification of a potential bottleneck in branched chain fatty acid incorporation into triacylglyc...