Document Detail


Protective effect of 3,4-methylenedioxyphenol (sesamol) on stress-related mucosal disease in rats.
MedLine Citation:
PMID:  23984371     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Stress-related mucosal disease (SRMD) causes considerable morbidity and mortality in critically ill patients. 3,4-Methylenedioxyphenol (sesamol) has been reported to have potent antioxidative and anti-inflammatory properties. The aim of this study was to investigate the effect of sesamol on water immersion restraint- (WIR-) induced SRMD in rats. Rat gastric ulcer and hemorrhage were induced by WIR. Rats were pretreated orally with various doses of sesamol (0.1, 0.3, and 1 mg/kg, resp.) 30 min before WIR. Gastric mucosal ulceration, hemoglobin, lipid peroxidation, mucus secretion, proinflammatory cytokines, and nuclear factor (NF)- κ B levels were determined 4 h after WIR. In addition, the infiltration of neutrophil and macrophage into gastric mucosa was also determined after WIR. Water immersion restraint increased gastric mucosal ulcer and hemorrhage, tumor necrosis factor (TNF)- α , interleukin (IL)-1 β , and IL-6 levels but failed to affect mucosal lipid peroxidation and mucus secretion compared with non-WIR. Sesamol significantly decreased gastric ulceration and hemorrhage and inhibited mucosal TNF- α , IL-1 β , and IL-6 production and NF- κ B activity in WIR-treated rats. In addition, increased myeloperoxidase and CD68 levels in gastric mucosa were found in WIR-treated rats compared to non-WIR rats. Sesamol did not affect myeloperoxidase but decreased CD68 levels in mucosa in WIR-treated rats. Sesamol may protect against SRMD by inhibiting gastric mucosal proinflammatory cytokines in rats.
Authors:
Dur-Zong Hsu; Yi-Wei Chen; Pei-Yi Chu; Srinivasan Periasamy; Ming-Yie Liu
Publication Detail:
Type:  Journal Article     Date:  2013-07-25
Journal Detail:
Title:  BioMed research international     Volume:  2013     ISSN:  2314-6141     ISO Abbreviation:  Biomed Res Int     Publication Date:  2013  
Date Detail:
Created Date:  2013-08-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101600173     Medline TA:  Biomed Res Int     Country:  United States    
Other Details:
Languages:  eng     Pagination:  481827     Citation Subset:  IM    
Affiliation:
Department of Environmental and Occupational Health, National Cheng Kung University Medical College, Tainan 70428, Taiwan.
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