Document Detail


Protective cardiovascular and renal actions of vitamin D and estrogen.
MedLine Citation:
PMID:  23277041     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Both basic science and clinical studies support the concept that vitamin D deficiency is involved in the pathogenesis of cardiovascular and renal diseases through its association with diabetes, obesity, and hypertension. Understanding the underlying mechanisms may provide a rationale for advocating adequate intake of vitamin D and calcium in all populations, thereby preventing many chronic diseases. This review explores the effect of vitamin D deficiency in the development of cardiovascular and renal diseases, and the role of vitamin D supplementation on cardiovascular outcomes. In addition, it highlights the importance of vitamin D intake for the prevention of adverse long-term health consequences, and in ways to facilitate the management of cardiovascular disease. This is particularly true for African American and postmenopausal women, who are at added risk for cardiovascular disease. We suggest that the negative cardiovascular effects of low vitamin D in postmenopausal women could be improved by a combined treatment of vitamin D and sex steroids acting through endothelium-dependent and/or -independent mechanisms, resulting in the generation of nitric oxide and calcitonin gene-related peptide (CGRP).
Authors:
Pandu R Gangula; Yuan-Lin Dong; Ayman Al-Hendy; Gloria Richard-Davis; Valerie Montgomery-Rice; Georges Haddad; Rihcard Millis; Susanne B Nicholas; Diane Moseberry
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2013-01-01
Journal Detail:
Title:  Frontiers in bioscience (Scholar edition)     Volume:  5     ISSN:  1945-0524     ISO Abbreviation:  Front Biosci (Schol Ed)     Publication Date:  2013  
Date Detail:
Created Date:  2013-01-01     Completed Date:  2013-09-09     Revised Date:  2014-05-29    
Medline Journal Info:
Nlm Unique ID:  101485241     Medline TA:  Front Biosci (Schol Ed)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  134-48     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cardiovascular Diseases / metabolism*,  prevention & control
Estrogens / metabolism*
Humans
Kidney Diseases / metabolism*,  prevention & control
Vitamin D / administration & dosage*,  metabolism*
Vitamin D Deficiency / drug therapy*,  metabolism*
Grant Support
ID/Acronym/Agency:
1 U54RR026138/RR/NCRR NIH HHS; 1 U54RR026140-01/RR/NCRR NIH HHS; G12 MD007597/MD/NIMHD NIH HHS; GM08016-38/GM/NIGMS NIH HHS; R21 DK076704/DK/NIDDK NIH HHS; U54 MD007593/MD/NIMHD NIH HHS; U54 MD007598/MD/NIMHD NIH HHS; U54 RR026140/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Estrogens; 1406-16-2/Vitamin D
Comments/Corrections

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