Document Detail

Protective and antioxidant effects of Rhizophora mangle L. against NSAID-induced gastric ulcers.
MedLine Citation:
PMID:  16182483     Owner:  NLM     Status:  MEDLINE    
The bark of Rhizophora mangle, the red mangrove, has been used traditionally in folk medicine of Caribbean countries due to its antiseptic, astringent, haemostatic and antifungal properties. Aqueous extracts are rich in tannins and have been proven experimentally to possess antibacterial, wound healing and antiulcerogenic effects. This work was designed to determine the gastroprotective effect of Rhizophora mangle in a model of diclofenac-induced ulcers in rats and to study the mechanisms involved, using the proton pump inhibitor omeprazole as a comparison. The lyophilized extract was given by oral gavage (125 and 62.5mg/kg) three times at 12h intervals before administering diclofenac 100mg/kg. Pretreatment with the extract resulted in a significant decrease of the ulcerated area (P<0.01). Rhizophora mangle induced a recovery of PGE(2) levels, which had been depleted by diclofenac. No anti-inflammatory effect was observed ex vivo or in vitro. The highest dose of the extract provoked a marked increase in glutathione peroxidase and superoxide dismutase activity, which was comparable to omeprazole. Furthermore, lipid peroxidation levels were inhibited in a dose-dependent manner. These results suggest that the gastroprotective effect of Rhizophora mangle in this experimental model appears through an antioxidant and prostaglandin-dependent way.
B Berenguer; L M Sánchez; A Quílez; M López-Barreiro; O de Haro; J Gálvez; M J Martín
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-09-22
Journal Detail:
Title:  Journal of ethnopharmacology     Volume:  103     ISSN:  0378-8741     ISO Abbreviation:  J Ethnopharmacol     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2005-12-19     Completed Date:  2006-05-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7903310     Medline TA:  J Ethnopharmacol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  194-200     Citation Subset:  IM    
Department of Pharmacology, Faculty of Pharmacy, Profesor García González Street No. 2, 41012 Seville, Spain.
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MeSH Terms
Anti-Inflammatory Agents, Non-Steroidal / antagonists & inhibitors,  toxicity*
Anti-Ulcer Agents / isolation & purification,  therapeutic use*
Antioxidants / isolation & purification,  therapeutic use*
Diclofenac / antagonists & inhibitors,  toxicity
Lipid Peroxidation / drug effects
Plant Bark*
Plant Extracts / isolation & purification,  therapeutic use*
Rats, Wistar
Stomach Ulcer / chemically induced,  pathology,  prevention & control*
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Anti-Ulcer Agents; 0/Antioxidants; 0/Plant Extracts; 15307-86-5/Diclofenac

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