Document Detail


Protective antigen in the membranes of mouse erythrocytes infected with Plasmodium chabaudi.
MedLine Citation:
PMID:  3670347     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A malarial antigen, Pc96, in the plasma membrane of erythrocytes infected with Plasmodium chabaudi has been identified. It is synthesized by the parasite and present during most of the growth stages of the intra-erythrocytic cycle as demonstrated by immunofluorescence. The antigen has a molecular weight of approximately 96,000. Monoclonal antibodies raised against this antigen were used to isolate the protein by affinity chromatography. Mice immunized with affinity-purified Pc96 were partially protected against blood induced-P. chabaudi infection. This result indicates the existence of a protective antigen in the membranes of erythrocytes parasitized by a rodent malaria and encourages the search for analogous antigens in human malaria parasites as possible candidate molecules for malaria vaccination.
Authors:
C Wanidworanun; J W Barnwell; H L Shear
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Molecular and biochemical parasitology     Volume:  25     ISSN:  0166-6851     ISO Abbreviation:  Mol. Biochem. Parasitol.     Publication Date:  1987 Sep 
Date Detail:
Created Date:  1987-12-01     Completed Date:  1987-12-01     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8006324     Medline TA:  Mol Biochem Parasitol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  195-201     Citation Subset:  IM    
Affiliation:
Department of Medical and Molecular Parasitology, New York University Medical Center, NY 10016.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antibodies, Monoclonal
Antibodies, Protozoan / biosynthesis
Antigens, Protozoan / analysis*,  biosynthesis,  immunology,  isolation & purification
Erythrocyte Membrane / immunology*
Erythrocytes / immunology,  parasitology*
Female
Immune Sera / immunology
Immunoassay
Malaria / prevention & control
Mice
Plasmodium / immunology*
Vaccination
Grant Support
ID/Acronym/Agency:
AI15235/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Antibodies, Protozoan; 0/Antigens, Protozoan; 0/Immune Sera

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