Document Detail


Protective and anti-arrhythmic effects of dauricine and verapamil on acute myocardial infarction in anesthetized dogs.
MedLine Citation:
PMID:  1442108     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Dauricine (Dau) 5 mg.kg-1 and verapamil (Ver) 0.15 mg.kg-1 iv followed by infusions of 0.1 and 0.01 mg.kg-1.min-1, respectively, for 30 min, depressed the elevated coronary venous blood LDH and CPK after LAD occlusion. Dau produced antagonistic effects on acute myocardial ischemia-induced ventricular ectopic activities (VE) and ventricular tachycardia (VT). The incidences of VE and VT in Ver group and ventricular fibrillation (VF) in both groups tended to descend. The results suggested that Dau and Ver produced marked protective effects on myocardial infarction and antagonized the acute ischemic arrhythmia.
Authors:
J Q Zhu; F D Zeng; C J Hu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Zhongguo yao li xue bao = Acta pharmacologica Sinica     Volume:  13     ISSN:  0253-9756     ISO Abbreviation:  Zhongguo Yao Li Xue Bao     Publication Date:  1992 May 
Date Detail:
Created Date:  1992-12-09     Completed Date:  1992-12-09     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8100330     Medline TA:  Zhongguo Yao Li Xue Bao     Country:  CHINA    
Other Details:
Languages:  eng     Pagination:  249-51     Citation Subset:  IM    
Affiliation:
Department of Clinical Pharmacology, Tongji Medical University, Hankou, China.
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MeSH Terms
Descriptor/Qualifier:
Alkaloids*
Animals
Anti-Arrhythmia Agents / pharmacology*,  therapeutic use
Arrhythmias, Cardiac / enzymology,  prevention & control*
Benzylisoquinolines*
Creatine Kinase / blood
Dogs
Female
Isoquinolines / pharmacology*,  therapeutic use
L-Lactate Dehydrogenase / blood
Male
Myocardial Infarction / enzymology,  prevention & control*
Tetrahydroisoquinolines*
Verapamil / pharmacology*,  therapeutic use
Chemical
Reg. No./Substance:
0/Alkaloids; 0/Anti-Arrhythmia Agents; 0/Benzylisoquinolines; 0/Isoquinolines; 0/Tetrahydroisoquinolines; 52-53-9/Verapamil; 524-17-4/dauricine; EC 1.1.1.27/L-Lactate Dehydrogenase; EC 2.7.3.2/Creatine Kinase

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