| Protective action of some Cu(II) complexes against photohemolysis induced by m. chloroperbenzoic acid. | |
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MedLine Citation:
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PMID: 9046106 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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m. Chloroperbenzoic acid (CPBA) was used as a photosensitizer in the photolysis of human red blood cells. Treatment of the cells with 25, 50 100, or 200 microM CPBA produced 3.5%, 85.9%, 252.6% or 350.9% photohemolysis, respectively, compared with untreated control cells. Some copper (II) complexes [CuL2] with SOD-like activity containing 2-methyl amino pyridine and various anions (Cl-, Br-, NO3-, ClO4-, or SO4--) were tested for their protective efficiency toward the cell damage photoinduced by CPBA. Treatment of the cells with maximum dose (200 microM) Cu(II), bromide, chloride, nitrate, sulfate, or perchlorate complexes with 2-methyl amino pyridine produced 85.87%, 59.28%, 49.29%, 33.47%, or 23.80% protection, respectively, against the cells irradiated without addition of Cu(II) complexes. A mechanism involving oxygen radicals and sensitizer photodegradation products was suggested to interpret the results. |
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Authors:
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M M el-Naggar |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of inorganic biochemistry Volume: 65 ISSN: 0162-0134 ISO Abbreviation: J. Inorg. Biochem. Publication Date: 1997 Mar |
Date Detail:
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Created Date: 1997-04-01 Completed Date: 1997-04-01 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7905788 Medline TA: J Inorg Biochem Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 263-6 Citation Subset: IM |
Affiliation:
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Department of Chemistry, Faculty of Science, University of Mansoura, Egypt. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Chlorobenzoates
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pharmacology* Copper / pharmacology* Free Radicals Hemolysis / drug effects* Humans Hydroxides / metabolism Methylphenazonium Methosulfate Oxygen / metabolism Photolysis / drug effects* Radiation-Sensitizing Agents / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Chlorobenzoates; 0/Free Radicals; 0/Hydroxides; 0/Radiation-Sensitizing Agents; 14280-30-9/hydroxide ion; 299-11-6/Methylphenazonium Methosulfate; 7440-50-8/Copper; 7782-44-7/Oxygen; 937-14-4/3-chloroperbenzoic acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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