| Protective action of ascorbic acid against mutagenicity of aminopyrine plus nitrite. | |
| | |
MedLine Citation:
|
PMID: 3913952 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Mutagenicity of aminopyrine and of aminopyrine plus nitrite was tested by the micronucleus test in bone marrow of mice and by host mediated mutagenicity assay with mice as host animals and S. typhimurium strain G 46. In parallel the possibility of the protective action of ascorbic acid was studied. Aminopyrine at the dose of 90 mg/kg po when administered to mice together with potassium nitrite induced a significant increase in the frequency of micronuclei in polychromatic erythrocytes and proved to be mutagenic for a Salmonella strain. In both systems mutagenicity of the combination of aminopyrine at this dose plus nitrite was abolished completely by ascorbic acid (373 or 622 mg/kg po). Ascorbic acid neither induced a significant increase in the frequency of micronuclei nor was mutagenic for the strain G 46. A formulation of aminopyrine with ascorbic acid is proposed. |
| | |
Authors:
|
K Pieńkowska; H Gajcy; J Koziorowska |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Polish journal of pharmacology and pharmacy Volume: 37 ISSN: 0301-0244 ISO Abbreviation: Pol J Pharmacol Pharm Publication Date: 1985 Sep-Oct |
Date Detail:
|
Created Date: 1986-04-25 Completed Date: 1986-04-25 Revised Date: 2003-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0366561 Medline TA: Pol J Pharmacol Pharm Country: POLAND |
Other Details:
|
Languages: eng Pagination: 601-7 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aminopyrine
/
antagonists & inhibitors,
toxicity* Animals Ascorbic Acid / pharmacology* Bone Marrow / ultrastructure Female Male Mice Mutagenicity Tests Mutation* Nitrites / antagonists & inhibitors, toxicity* Nitroso Compounds / toxicity Salmonella typhimurium / genetics |
| Chemical | |
Reg. No./Substance:
|
0/Nitrites; 0/Nitroso Compounds; 50-81-7/Ascorbic Acid; 58-15-1/Aminopyrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: What's new in light and electron microscopic immunocytochemistry? Application of the protein A-gold ...
Next Document: Blood glucose and insulin concentration in rats subjected to physical exercise in acute poisoning wi...