| Protective role of three vegetable peels in alloxan induced diabetes mellitus in male mice. | |
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MedLine Citation:
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PMID: 20614191 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The hitherto unknown glucose regulating role of three vegetable peels from cucurbitaceae family was evaluated. In a preliminary study, effects of ethanolic extracts of Cucurbita pepo, Cucumis sativus and Praecitrullus fistulosus peels were studied at 250 and 500 mg kg(-1) d(-1) for 15 days in the alterations in serum glucose and in hepatic lipid peroxidation (LPO) in male mice. In the pilot experiment, the effective and safe concentration of each peel was administered (p.o.) for 10 consecutive days and then on 11th and 12th days alloxan was administered along with peel extracts. The treatment was continued up to 15th day. At the end, alterations in serum glucose, insulin, triiodothyronine, thyroxine, total cholesterol, triglyceride, high density lipoprotein, low density lipoprotein, very low density lipoprotein, hepatic lipid peroxidation, superoxide dismutase and catalase were studied. All the three peel extracts nearly reversed most of these changes induced by alloxan suggesting their possible role in ameliorating diabetes mellitus and related changes in serum lipids. However, Cucurbita pepo peel was found to be the most effective. Total polyphenols, flavonoids and ascorbic acid contents of the test peels were also estimated, which appear to be associated with the observed antidiabetic and antioxidative potentials. |
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Authors:
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Yamini Dixit; Anand Kar |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Plant foods for human nutrition (Dordrecht, Netherlands) Volume: 65 ISSN: 1573-9104 ISO Abbreviation: Plant Foods Hum Nutr Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-24 Completed Date: 2011-01-31 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8803554 Medline TA: Plant Foods Hum Nutr Country: Netherlands |
Other Details:
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Languages: eng Pagination: 284-9 Citation Subset: IM |
Affiliation:
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Endocrine Research Unit, School of Life Sciences,Takshashila Campus, Devi Ahilya Vishwavidhyalaya, Khandwa Road, Indore, MP, India. yamini.dixit@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Ascorbic Acid / analysis, pharmacology, therapeutic use Blood Glucose / metabolism* Catalase / blood Cucurbitaceae / chemistry* Diabetes Mellitus, Experimental / drug therapy* Flavonoids / analysis, pharmacology, therapeutic use Fruit Hypoglycemic Agents / analysis, pharmacology, therapeutic use* Insulin / blood Lipid Peroxidation Lipids / blood* Liver / metabolism Male Mice Phenols / analysis, pharmacology, therapeutic use Phytotherapy* Plant Extracts / chemistry, pharmacology, therapeutic use* Superoxide Dismutase / blood Thyroxine / blood Triiodothyronine / blood Vegetables Vitamins / analysis, pharmacology, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Flavonoids; 0/Hypoglycemic Agents; 0/Lipids; 0/Phenols; 0/Plant Extracts; 0/Vitamins; 0/polyphenols; 11061-68-0/Insulin; 50-81-7/Ascorbic Acid; 6893-02-3/Triiodothyronine; 7488-70-2/Thyroxine; EC 1.11.1.6/Catalase; EC 1.15.1.1/Superoxide Dismutase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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