| Protective Effects of CAPE on Liver Injury Induced by CCL(4): An Electron Microscopy Study. | |
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MedLine Citation:
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PMID: 21265632 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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This study was designed to investigate the protective effects of caffeic acid phenethyl ester on carbon tetrachloride-induced liver damage in rats. Twenty-four male Wistar rats were divided in three groups. Group I was used as control. Rats in group II were injected with carbon tetrachloride every other day for 1 month, whereas rats in group III were injected with carbon tetrachloride and caffeic acid phenethyl ester every other day for 1 month. At the end of the experiment, all animals were killed by decapitation and their livers were removed. Liver tissues were processed for electron microscopy. Histopathologically, hepatocytes of rats treated with carbon tetrachloride had damage in the cytoplasmic organelles and nuclei membranes as well as an excessive lipid accumulation in the hepatocytes. However, those histopathological changes were reduced with the coadministration of carbon tetrachloride and caffeic acid phenethyl ester. We conclude that caffeic acid phenethyl ester treatment has the capability to prevent carbon tetrachloride-induced liver damage in rats. |
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Authors:
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Neriman Colakoglu; Ilter Kus; Aysel Kukner; Hidir Pekmez; Enver Ozan; Mustafa Sarsilmaz |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Ultrastructural pathology Volume: 35 ISSN: 1521-0758 ISO Abbreviation: Ultrastruct Pathol Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-01-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8002867 Medline TA: Ultrastruct Pathol Country: England |
Other Details:
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Languages: eng Pagination: 26-30 Citation Subset: IM |
Affiliation:
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Firat University, Medical Faculty, Histology& Embryology Department, Elazig, Turkey. |
Export Citation:
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Descriptor/Qualifier:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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