| Protective Effects of Adeno-associated Virus Mediated Brain-derived Neurotrophic Factor Expression on Retinal Ganglion Cells in Diabetic Rats. | |
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MedLine Citation:
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PMID: 22297541 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Adeno-associated virus vector plasmid carrying the expression cassette of brain-derived neurotrophic factor (BDNF), pAAV-BDNF, was constructed and packaged into recombinant adeno-associated virus (rAAV-BDNF). The rAAV-BDNF was intravitreally injected into streptzotocin (STZ)-induced diabetic Sprague-Dawley (SD) Rats. Data showed that over-expression of BDNF could increase alive retinal ganglion cell (RGC) number and improve its function in streptzotocin(STZ)-induced diabetic rats, which might be a new method to treat diabetic neuropathy and retinopathy. |
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Authors:
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Yan Gong; Zhan-Ping Chang; Ruo-Tong Ren; Shi-Hui Wei; Huan-Fen Zhou; Xiao-Fei Chen; Bao-Ke Hou; Xin Jin; Mao-Nian Zhang |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-2-2 |
Journal Detail:
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Title: Cellular and molecular neurobiology Volume: - ISSN: 1573-6830 ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-2-2 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8200709 Medline TA: Cell Mol Neurobiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Ophthalmology, Chinese PLA General Hospital, No. 28, Fuxing Road, Haidian District, 100853, Beijing, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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