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The Protective Effect of Mitochondrial ATP-Sensitive K(+) Channel Opener, Nicorandil, Combined With Na (+)/Ca (2+) Exchange Blocker KB-R7943 on Myocardial Ischemia-Reperfusion Injury in Rat.
MedLine Citation:
PMID:  21132540     Owner:  NLM     Status:  In-Data-Review    
To study the protective effect of mitochondrial ATP-sensitive K(+) channel (mitoK(ATP) channel) opener, nicorandil, combined with Na(+)/Ca(2+) exchange blocker KB-R7943 on myocardial ischemia-reperfusion injury in isolated rat hearts; the isolated rat heart was perfused by modified Langendorff device, after 15-min balanced perfusion, 45-min ischemia (about left and right coronary perfusion flow reduced to 5% of the original irrigation flow), and 2-h reperfusion were performed. Forty Wistar rats were randomly divided into four groups: control group, nicorandil group, KB-R7943 group, and the combination of nicorandil and KB-R7943 group. After 45-min ischemia and then 2-h reperfusion, the myocardial infarct size was 34.31% in control group, 26.35% in nicorandil group, 28.74% in KB-R7943 group, and 19.23% in combination of nicorandil and KB-R7943 group. SOD activity in coronary perfusion fluid was the highest in the combination of nicorandil and KB-R7943 group, and MDA content was the lowest. In the combination drug group compared with the control group, myocardial ultrastructural injury was significantly reduced. The combination of nicorandil and KB-R7943 significantly reduced myocardial infarct size, significantly reduced myocardial ultrastructural damage, could increase coronary perfusion fluid SOD activity, and reduced MDA levels.
Dalin Jia
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cell biochemistry and biophysics     Volume:  60     ISSN:  1559-0283     ISO Abbreviation:  Cell Biochem. Biophys.     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-06-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9701934     Medline TA:  Cell Biochem Biophys     Country:  United States    
Other Details:
Languages:  eng     Pagination:  219-24     Citation Subset:  IM    
Department of Cardiology, The First Affiliated Hospital, University of China Medical, China Medical University, 155th North of Nanjing Street, Heping District, Shenyang, 110001, Liaoning Province, China,
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