| Protective effect of L-arginine in experimentally induced myocardial ischemia: comparison with aspirin. | |
| | |
MedLine Citation:
|
PMID: 20938038 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
OBJECTIVE: Coronary artery diseases including myocardial ischemia (MI) remain one of the leading causes of death worldwide. This study was designed to compare the protective effect of L-arginine versus aspirin from the biochemical changes associated with MI injury. Experimental design: Four groups of male New Zealand white rabbits were investigated. Normal group (n = 8) rabbits were fed standard chow pellets, untreated MI group (n = 16), where hypercholesterolemia was induced by feeding the animals with a diet containing 2% cholesterol for 28 days, L-arginine group (n = 12) rabbits were fed a 2% cholesterol-enriched diet in conjunction with L-arginine (2.25 g %) in drinking water for 28 days, and aspirin group (n = 12) rabbits were fed 2% cholesterol-enriched diet in conjunction with aspirin administered orally (0.7 mg/kg per d) for 28 days. After 28 days, MI was induced in all groups, except the normal group, by a single subcutaneous (sc) injection of isoproterenol hydrochloride (0.2 mg/kg body weight [bw]). Animals were sacrificed 6 hours later. RESULTS: Our results showed that L-arginine was more effective than aspirin in reducing platelet aggregation, reducing low-density lipoprotein (LDL) oxidizability, preventing aortic intimal thickening, and maintaining histological architecture of the myocardium. Both drugs, however, had similar positive effects on plasma fibrinogen levels and on the prevention of myocardial release of cardiac troponin I and creatine kinase-MB. The effect on hypercholesterolemia was insignificant for both drugs. Aspirin was more effective than L-arginine in prolonging prothrombin time. CONCLUSION: L-arginine supplementation represents a potentially novel nutritional strategy for preventing and treating coronary artery diseases especially in cases of aspirin resistance and/or hypersensitivity. |
| | |
Authors:
|
Alaaeldin I Saleh; Sahar M Abdel Maksoud; Shohda A El-Maraghy; Mohamed Z Gad |
Related Documents
:
|
19165358 - Effect of l- arginine on electrocardiographic changes induced by hypercholesterolemia a... 12957678 - A casein variant in cow's milk is atherogenic. 1823918 - Protective effect of selenium and vitamin e against changes induced in heart vessels of... 7247998 - Effect of ch-1243, a pyrido (1,2-a) pyrimidine derivative on the elevated activity of l... 16950168 - Impact of low high-density lipoproteins on in-hospital events and one-year clinical out... 20338998 - Parp1 deficiency exacerbates diet-induced obesity in mice. |
Publication Detail:
|
Type: Journal Article Date: 2010-10-11 |
Journal Detail:
|
Title: Journal of cardiovascular pharmacology and therapeutics Volume: 16 ISSN: 1940-4034 ISO Abbreviation: J. Cardiovasc. Pharmacol. Ther. Publication Date: 2011 Mar |
Date Detail:
|
Created Date: 2011-02-09 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9602617 Medline TA: J Cardiovasc Pharmacol Ther Country: United States |
Other Details:
|
Languages: eng Pagination: 53-62 Citation Subset: IM |
Affiliation:
|
Biochemistry Department, Faculty of Pharmacy, German University in Cairo, New Cairo, Egypt. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Review article: combination of clopidogrel and proton pump inhibitors: implications for clinicians.
Next Document: A randomized trial of aspirin at clinically relevant doses and nitric oxide formation in humans.