| Protective effect of erythropoietin on renal injury induced by acute exhaustive exercise in the rat. | |
| | |
MedLine Citation:
|
PMID: 21072740 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
We investigated the protective effect of Erythropoietin (EPO) analogue rHuEPO on renal injury induced by acute exhaustive exercise in the rat. Rats were randomly allocated to one of 3 groups: normal control (C), exhaustive exercise test (ET) and EPO pre-treatment (rHuEPO 2 000 U/kg) plus ET (EPO+ET). Compared with controls, animals in the ET group had increased serum urea nitrogen, serum creatinine, urine protein, and renal tissue malondialdehyde (MDA) and decreased renal tissue nitric oxide (NO), nitric oxide synthase (NOS) and superoxide dismutase (SOD) activities. There was severe damage in renal tubular epithelial cells with a lot of cell apoptosis, and TUNEL assay revealed a remarkably high apoptotic index (p<0.01). Changes in renal function and kidney tissue were much less in the EPO+ET group (p<0.05) and the apoptotic index was much lower than in the ET group (18.45±0.32 vs. 27.55±0.49, p<0.05). EPO pretreatment thus significantly prevented renal cell apoptosis, and counteracted high MDA and low NO and NOS renal contents induced by exhaustive exercise. The data point to a potential value of EPO in preventing the acute renal injury after exhaustive exercise. |
| | |
Authors:
|
X Lin; S Qu; M Hu; C Jiang |
Publication Detail:
|
Type: Journal Article Date: 2010-11-11 |
Journal Detail:
|
Title: International journal of sports medicine Volume: 31 ISSN: 1439-3964 ISO Abbreviation: Int J Sports Med Publication Date: 2010 Dec |
Date Detail:
|
Created Date: 2010-12-17 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8008349 Medline TA: Int J Sports Med Country: Germany |
Other Details:
|
Languages: eng Pagination: 847-53 Citation Subset: IM |
Copyright Information:
|
© Georg Thieme Verlag KG Stuttgart · New York. |
Affiliation:
|
Medical College of Hunan Normal University, Changsha, China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Gender muscle recovery during isokinetic exercise.
Next Document: Incidence of the plateau at V?O 2max is dependent on the anaerobic capacity.