Document Detail

Protective effect of dimethyl sulfoxide on acute myocardial infarction in rats.
MedLine Citation:
PMID:  19904216     Owner:  NLM     Status:  MEDLINE    
Dimethyl sulfoxide (DMSO) is an organic compound widely used as solvent in biological studies and as vehicle for drug administration. DMSO has been shown to possess several biological effects, including antioxidant, anti-inflammatory, antinociceptive effects, and it has been proposed to be therapeutic in several disorders, such as gastrointestinal diseases, rheumatologic diseases, and for the treatment of several manifestations of amyloidosis. To better define the biological profile of DMSO, we investigated its effect on an in vivo model of acute myocardial infarction in rats, caused by left anterior descending coronary artery ligation. Our results show that pretreatment of rats with intraperitoneal (ip) DMSO (500 microL/Kg) for 3 consecutive days before left anterior descending coronary artery ligation significantly (P < 0.05) reduced cardiac damage from 18.75 +/- 4.88% (n = 12) to 4.46 +/- 2.01% (n = 8); serum levels of troponin I from 29.35 +/- 12.32 ng/mL (n = 8) to 2.95 +/- 1.32 ng/mL (n = 4); and serum levels of myoglobin from 46.86 +/- 10.35 ng/mL (n = 7) to 13.75 +/- 0.85 ng/mL (n = 4). Our data demonstrate that DMSO has a protective effect in a model of acute myocardial infarction in rats.
Antonio Parisi; Alessio Alfieri; Marialuisa Mazzella; Antonio Mazzella; Mattia Scognamiglio; Gianluigi Scognamiglio; Nicola Mascolo; Carla Cicala
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  55     ISSN:  1533-4023     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-01-22     Completed Date:  2010-04-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  106-9     Citation Subset:  IM    
Dipartimento di Farmacologia Sperimentale, Universit? degli Studi di Napoli Federico II, Napoli, Italy.
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MeSH Terms
Antioxidants / pharmacology*
Dimethyl Sulfoxide / pharmacology*
Disease Models, Animal
Injections, Intraperitoneal
Myocardial Infarction / drug therapy*,  physiopathology
Myoglobin / blood,  drug effects
Rats, Wistar
Troponin I / blood,  drug effects
Reg. No./Substance:
0/Antioxidants; 0/Myoglobin; 0/Troponin I; 67-68-5/Dimethyl Sulfoxide

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