Document Detail


Protective effect of dietary potassium against cardiovascular damage in salt-sensitive hypertension: possible role of its antioxidant action.
MedLine Citation:
PMID:  19485915     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
It is well known that high salt intake induces hypertension and cardiovascular damage, while dietary potassium supplementation counteracts these harmful effects. Actually, the protective effect of potassium is strengthened with excess salt as compared with salt depletion. Although the precise mechanisms have not been fully elucidated, in our previous reports, the antihypertensive effect of dietary potassium was accompanied by sympathetic nerve inhibition in salt-sensitive hypertension. Also, potassium supplement suppressed salt-induced insulin resistance. These effects of dietary potassium can explain its cardio- and vasculo-protective action in addition to the potassium supplementation induced decreased salt-induced rise in blood pressure. On the other hand, salt-sensitive hypertension is associated with reactive oxygen species (ROS) overproduction. Moreover, sympathoexcitation can be induced by central ROS upregulation and insulin resistance can be caused by ROS excess in the target organs of insulin, such as skeletal muscle. Conversely, the seemingly different actions of potassium can be explained by the antioxidant effect of dietary potassium; in our recent studies, potassium supplementation inhibits salt-induced progress of cardiac diastolic dysfunction and vascular neointima formation by cuff placement around arteries, associated with the inhibition of regional ROS overproduction, in salt-sensitive hypertension. Thus, it is possible that dietary potassium protects against salt-induced cardiovascular damage by the reduction of ROS generation and by central sympatholytic action and amelioration of insulin resistance induced through its antioxidant effect.
Authors:
Katsuyuki Ando; Hiromitsu Matsui; Megumi Fujita; Toshiro Fujita
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Current vascular pharmacology     Volume:  8     ISSN:  1875-6212     ISO Abbreviation:  Curr Vasc Pharmacol     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-04-09     Completed Date:  2010-08-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101157208     Medline TA:  Curr Vasc Pharmacol     Country:  United Arab Emirates    
Other Details:
Languages:  eng     Pagination:  59-63     Citation Subset:  IM    
Affiliation:
Department of Nephrology and Endocrinology, University of Tokyo Graduate School of Medicine, Tokyo, 112-8655, Japan. katsua-tky@umin.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Animals
Antioxidants / therapeutic use*
Cardiovascular Diseases / complications,  physiopathology*,  prevention & control*
Dietary Supplements
Disease Progression
Humans
Hypertension / complications,  metabolism,  physiopathology*,  therapy*
Insulin Resistance / physiology
Oxidative Stress / physiology
Potassium, Dietary / therapeutic use*
Reactive Oxygen Species / agonists,  antagonists & inhibitors,  metabolism
Sodium Chloride, Dietary / administration & dosage,  adverse effects*
Sodium, Dietary / administration & dosage,  adverse effects
Sympathetic Nervous System / physiopathology
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Potassium, Dietary; 0/Reactive Oxygen Species; 0/Sodium Chloride, Dietary; 0/Sodium, Dietary

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