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Protective Effect of Caffeine Administration on Myocardial Ischemia/Reperfusion Injury in Rats.
MedLine Citation:
PMID:  21558980     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Many studies have examined the association between coffee consumption and risk of cardiovascular disease, but the results still remain controversial. Caffeine is one of the main biologically active compounds of coffee. The aim of this study was to investigate the potential role of caffeine on myocardial ischemia/reperfusion (I/R) injury in the rats. We administrated caffeine (25mg/kg/day) or saline in rats for 4 weeks before myocardial ischemia/reperfusion operation. Compared with the Sham group, Caffeine treatment decreased ischemia associated infarct size, serum creatine kinase (CK) and lactate dehydrogenase (LDH) 3 hours reperfusion after 30 minutes ischemia. Myocardial neutrophil infiltration (assessed by myeloperoxidase activity) was significantly decreased compared to the control group. Meanwhile, caffeine reduced the myocardial apoptosis and suppressed the activation of caspase-3 during myocardial I/R. Importantly, we observed a strong poly (ADP-ribose) polymerase (PARP) activation during myocardial I/R, and caffeine administration inhibited PARP activation and attenuated the expression of PARP-related pro-inflammatory mediators such as inducible nitric-oxide synthetase (iNOS), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α), all of which may be correlated with down-regulated nuclear factor-κB (NF-κB) activity. We concluded that caffeine protected against myocardial I/R injury by inhibiting inflammation and apoptosis.
Authors:
Xu-Yong Li; Lin Xu; Guo-Sheng Lin; Xiao-Yan Li; Xue-Jun Jiang; Tao Wang; Jing-Jun Lu; Bin Zeng
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-5-7
Journal Detail:
Title:  Shock (Augusta, Ga.)     Volume:  -     ISSN:  1540-0514     ISO Abbreviation:  -     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-5-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9421564     Medline TA:  Shock     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
1Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, P.R. China 2Cardiovascular Research Institute,Wuhan University, Wuhan 430060, P.R. China.
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