Document Detail


Protection with combinations of hydroxytryptophan and some thiol compounds against whole-body gamma irradiation.
MedLine Citation:
PMID:  6347927     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Protection of mice (as measured by survival at 30 days) against whole-body gamma exposure by prior treatment with combinations of hydroxytryptophan (HT) and some thiol drugs, is reported here. The combination of HT and aminoethylisothiuronium bromide hydrobromide (AET) was much more effective than HT alone against the effects of 10.5 and 12.5 Gy of gamma ray exposure. A combination of HT and beta-mercaptopropionylglycine (MPG) gave marked protection against a 10.5 Gy exposure but not against 12.5 Gy. The combination of HT with cysteine or cysteamine also provided reasonable protection against 10.5 Gy. The combination of HT and cystamine rendered a low level of protection against 10.5 Gy, but again it was better than HT alone. The thiol drugs by themselves in the doses used in combination were ineffective in rendering protection after whole body gamma ray exposure.
Authors:
A Ghose; S K Ganguly; J Kaur
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of radiation biology and related studies in physics, chemistry, and medicine     Volume:  44     ISSN:  0020-7616     ISO Abbreviation:  Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med.     Publication Date:  1983 Aug 
Date Detail:
Created Date:  1983-09-23     Completed Date:  1983-09-23     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0374725     Medline TA:  Int J Radiat Biol Relat Stud Phys Chem Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  175-81     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cobalt Radioisotopes
Cystamine / administration & dosage
Cysteamine / administration & dosage
Cysteine / administration & dosage
Drug Therapy, Combination
Gamma Rays
Injections, Intraperitoneal
Mice
Mice, Inbred Strains
Radiation Injuries, Experimental / prevention & control*
Radiation-Protective Agents / administration & dosage*
Serotonin / administration & dosage*
Sulfhydryl Compounds / administration & dosage*
Thiopronine / administration & dosage
Whole-Body Irradiation
beta-Aminoethyl Isothiourea / administration & dosage
Chemical
Reg. No./Substance:
0/Cobalt Radioisotopes; 0/Radiation-Protective Agents; 0/Sulfhydryl Compounds; 151-16-6/beta-Aminoethyl Isothiourea; 1953-02-2/Thiopronine; 50-67-9/Serotonin; 51-85-4/Cystamine; 52-90-4/Cysteine; 60-23-1/Cysteamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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