| Protection with combinations of hydroxytryptophan and some thiol compounds against whole-body gamma irradiation. | |
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MedLine Citation:
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PMID: 6347927 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Protection of mice (as measured by survival at 30 days) against whole-body gamma exposure by prior treatment with combinations of hydroxytryptophan (HT) and some thiol drugs, is reported here. The combination of HT and aminoethylisothiuronium bromide hydrobromide (AET) was much more effective than HT alone against the effects of 10.5 and 12.5 Gy of gamma ray exposure. A combination of HT and beta-mercaptopropionylglycine (MPG) gave marked protection against a 10.5 Gy exposure but not against 12.5 Gy. The combination of HT with cysteine or cysteamine also provided reasonable protection against 10.5 Gy. The combination of HT and cystamine rendered a low level of protection against 10.5 Gy, but again it was better than HT alone. The thiol drugs by themselves in the doses used in combination were ineffective in rendering protection after whole body gamma ray exposure. |
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Authors:
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A Ghose; S K Ganguly; J Kaur |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: International journal of radiation biology and related studies in physics, chemistry, and medicine Volume: 44 ISSN: 0020-7616 ISO Abbreviation: Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. Publication Date: 1983 Aug |
Date Detail:
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Created Date: 1983-09-23 Completed Date: 1983-09-23 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0374725 Medline TA: Int J Radiat Biol Relat Stud Phys Chem Med Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 175-81 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cobalt Radioisotopes Cystamine / administration & dosage Cysteamine / administration & dosage Cysteine / administration & dosage Drug Therapy, Combination Gamma Rays Injections, Intraperitoneal Mice Mice, Inbred Strains Radiation Injuries, Experimental / prevention & control* Radiation-Protective Agents / administration & dosage* Serotonin / administration & dosage* Sulfhydryl Compounds / administration & dosage* Thiopronine / administration & dosage Whole-Body Irradiation beta-Aminoethyl Isothiourea / administration & dosage |
| Chemical | |
Reg. No./Substance:
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0/Cobalt Radioisotopes; 0/Radiation-Protective Agents; 0/Sulfhydryl Compounds; 151-16-6/beta-Aminoethyl Isothiourea; 1953-02-2/Thiopronine; 50-67-9/Serotonin; 51-85-4/Cystamine; 52-90-4/Cysteine; 60-23-1/Cysteamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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