Document Detail

Protection of vitamin E, selenium, trolox C, ascorbic acid palmitate, acetylcysteine, coenzyme Q0, coenzyme Q10, beta-carotene, canthaxanthin, and (+)-catechin against oxidative damage to rat blood and tissues in vivo.
MedLine Citation:
PMID:  7797106     Owner:  NLM     Status:  MEDLINE    
Male Sprague-Dawley rats were fed either a vitamin E and selenium deficient diet, a diet supplemented with vitamin E and selenium, or a diet supplemented with vitamin E, selenium, trolox C, ascorbic acid palmitate, acetylcysteine, Beta-carotene, canthaxanthin, coenzyme Q0, coenzyme Q10, and (+)-catechin. Rats were injected with CBrCl3 (0.05 mmol/100 g body weight) intraperitoneally. Oxidative damage to tissues was measured by formation of oxidized heme proteins (OHP) in blood, liver, kidney, heart, lung, and spleen. Diets supplemented with antioxidants showed protection against oxidative damage caused by CBrCl3. The protection was dependent on the diversity and quantity of antioxidants in the diet. In general, diets supplemented with both fat soluble and water soluble antioxidants provided better protection than diets supplemented only with vitamin E and selenium or with vitamin E, selenium, and fat soluble antioxidants.
H Chen; A L Tappel
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Free radical biology & medicine     Volume:  18     ISSN:  0891-5849     ISO Abbreviation:  Free Radic. Biol. Med.     Publication Date:  1995 May 
Date Detail:
Created Date:  1995-08-03     Completed Date:  1995-08-03     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8709159     Medline TA:  Free Radic Biol Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  949-53     Citation Subset:  IM    
Department of Pharmacology, School of Medicine, University of Washington, Seattle, USA.
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MeSH Terms
Acetylcysteine / pharmacology
Antioxidants / pharmacology*
Ascorbic Acid / pharmacology
Canthaxanthin / pharmacology
Carotenoids / pharmacology
Catechin / pharmacology
Chromans / pharmacology
Heart / drug effects
Hemeproteins / drug effects,  metabolism*
Kidney / drug effects,  metabolism
Liver / drug effects,  metabolism
Lung / drug effects,  metabolism
Myocardium / metabolism
Oxidative Stress / drug effects*
Palmitic Acid
Palmitic Acids / pharmacology
Rats, Sprague-Dawley
Selenium / deficiency,  pharmacology
Spleen / drug effects,  metabolism
Ubiquinone / analogs & derivatives,  pharmacology
Vitamin E / pharmacology
Vitamin E Deficiency / blood,  metabolism
beta Carotene
Grant Support
Reg. No./Substance:
0/Antioxidants; 0/Chromans; 0/Coenzymes; 0/Hemeproteins; 0/Palmitic Acids; 1339-63-5/Ubiquinone; 1406-18-4/Vitamin E; 154-23-4/Catechin; 303-98-0/coenzyme Q10; 36-88-4/Carotenoids; 50-81-7/Ascorbic Acid; 514-78-3/Canthaxanthin; 56305-04-5/6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid; 57-10-3/Palmitic Acid; 616-91-1/Acetylcysteine; 7235-40-7/beta Carotene; 7782-49-2/Selenium

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