| Protection of retinal vasculature by losartan against apoptosis and vasculopathy in rats with spontaneous hypertension. | |
| | |
MedLine Citation:
|
PMID: 20051910 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVES: Retinal blood vessels may develop vasculopathy and apoptosis in response to hypertension. The present study was aimed at testing the role of losartan, a specific antagonist of angiotensin II receptor type 1 receptor in regulation of vascular apoptosis in retinal vasculature with hypertension. METHODS: Losartan potassium was administered to spontaneously hypertensive rats (SHR). Blood pressure was measured in SHR as well as normotensive Wistar-Kyoto rats (WKY). Eye fundus was examined in living animals and then tissue specimens were collected for histochemistry by hematoxylin and eosin staining, terminal deoxynucleotidyl transferase-mediated 2'-deoxyuridine 5'-triphosphate nick end labeling (TUNEL), immunohistochemistry and transmission electron microscopy. RESULTS: Losartan treatment for 4-8 weeks reduced blood pressure of SHR to the normal levels seen in WKY. The losartan-treated SHR showed marked improvement of retinal vascular morphology compared with untreated SHR. The retinal blood networks of the treated SHR developed lower degrees of vasculopathy and apoptosis. TUNEL and transmission electron microscopy also revealed that losartan exerted its protective effects not only on endothelial cells but on pericytes as well. The blood vessels of losartan-treated animals also showed decreased expression of bax with elevation of B-cell CLL/lymphoma 2. CONCLUSION: Treatment with losartan, a medicine that lowers blood pressure by blocking angiotensin II receptor type 1 receptor, can protect the retinal vasculature against hypertensive vascular injury by inhibiting apoptosis of vascular cells and by preventing hypertensive retinopathy. |
| | |
Authors:
|
Deye Yang; Mingying Zhang; Xiaoyan Huang; Fei Fang; Bixin Chen; Saibin Wang; Jianqiu Cai; Xiangxiang Shi; Jia Qu; Yong-Jian Geng |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of hypertension Volume: 28 ISSN: 1473-5598 ISO Abbreviation: J. Hypertens. Publication Date: 2010 Mar |
Date Detail:
|
Created Date: 2010-02-17 Completed Date: 2010-06-01 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8306882 Medline TA: J Hypertens Country: England |
Other Details:
|
Languages: eng Pagination: 510-9 Citation Subset: IM |
Affiliation:
|
The First Affiliated Hospital of Wenzhou Medical College, Wenzhou, China. deyeyang203@hotmail.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Angiotensin II Type 1 Receptor Blockers
/
pharmacology*,
therapeutic use Animals Apoptosis / drug effects* Blood Pressure / drug effects Endothelium, Vascular / drug effects Flow Cytometry Hypertension / drug therapy*, pathology Immunohistochemistry In Situ Nick-End Labeling Losartan / pharmacology*, therapeutic use Rats Rats, Inbred SHR Rats, Inbred WKY Retinal Vessels / drug effects*, pathology Umbilical Veins / drug effects Vascular Diseases / prevention & control* |
| Chemical | |
Reg. No./Substance:
|
0/Angiotensin II Type 1 Receptor Blockers; 114798-26-4/Losartan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Social integration, social contacts, and blood pressure dipping in African-Americans and whites.
Next Document: Antihypertensive medications and risk of community-acquired pneumonia.