| Protection and replication of telomeres in fission yeast. | |
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MedLine Citation:
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PMID: 19898524 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Telomeres, the natural ends of linear chromosomes, must be protected and completely replicated to guarantee genomic stability in eukaryotic cells. However, the protected state of telomeres is not compatible with recruitment of telomerase, an enzyme responsible for extending telomeric G-rich repeats during S-phase; thus, telomeres must undergo switches from a protected state to an accessible state during the cell cycle. In this minireview, we will summarize recent advances in our understanding of proteins involved in the protection and replication of telomeres, and the way these factors are dynamically recruited to telomeres during the cell cycle. We will focus mainly on recent results from fission yeast Schizosaccharomyces pombe, and compare them with results from budding yeast Saccharomyces cerevisiae and mammalian cell studies. In addition, a model for the way in which fission yeast cells replicate telomeres will be presented. |
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Authors:
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Bettina A Moser; Toru M Nakamura |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
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Title: Biochemistry and cell biology = Biochimie et biologie cellulaire Volume: 87 ISSN: 1208-6002 ISO Abbreviation: Biochem. Cell Biol. Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-11-09 Completed Date: 2010-01-28 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 8606068 Medline TA: Biochem Cell Biol Country: Canada |
Other Details:
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Languages: eng Pagination: 747-58 Citation Subset: IM |
Affiliation:
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Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, 900 S. Ashland Ave. MC669, Chicago, IL 60607, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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DNA Replication
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physiology* Genomic Instability / physiology Models, Biological Schizosaccharomyces / genetics*, metabolism, physiology Schizosaccharomyces pombe Proteins / metabolism, physiology Telomerase / metabolism, physiology Telomere / genetics*, metabolism* Telomere-Binding Proteins / metabolism, physiology |
| Grant Support | |
ID/Acronym/Agency:
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GM078253/GM/NIGMS NIH HHS; R01 GM078253-03/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Schizosaccharomyces pombe Proteins; 0/Stn1 protein, S pombe; 0/Telomere-Binding Proteins; 0/Ten1 protein, S pombe; EC 2.7.7.49/Telomerase |
| Comments/Corrections | |
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