Document Detail

Protection of organs other than the heart by remote ischemic conditioning.
MedLine Citation:
PMID:  23079610     Owner:  NLM     Status:  MEDLINE    
Organ or tissue dysfunction due to acute ischemia-reperfusion injury (IRI) is the leading cause of death and disability worldwide. Acute IRI induces cell injury and death in a wide variety of organs and tissues in a large number of different clinical settings. One novel therapeutic noninvasive intervention, capable of conferring multiorgan protection against acute IRI, is 'remote ischemic conditioning' (RIC). This describes an endogenous protective response to acute IRI, which is triggered by the application of one or more brief cycles of nonlethal ischemia and reperfusion to one particular organ or tissue. Originally discovered as a therapeutic strategy for protecting the myocardium against acute IRI, it has been subsequently demonstrated that RIC may confer protection against acute IRI in a number of different noncardiac organs and tissues including the kidneys, lungs, liver, skin flaps, ovaries, intestine, stomach and pancreas. The discovery that RIC can be induced noninvasively by applying the RIC stimulus to the skeletal tissue of the upper or lower limb has facilitated its application to a number of clinical settings in which organs and tissues are at high risk of acute IRI. In this article, we review the experimental studies that have investigated RIC in organs and tissues other than the heart, and we explore the therapeutic potential of RIC in preventing organ and tissue dysfunction induced by acute IRI.
Luciano Candilio; Abdul Malik; Derek J Hausenloy
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Journal of cardiovascular medicine (Hagerstown, Md.)     Volume:  14     ISSN:  1558-2035     ISO Abbreviation:  J Cardiovasc Med (Hagerstown)     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-15     Completed Date:  2013-07-17     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  101259752     Medline TA:  J Cardiovasc Med (Hagerstown)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  193-205     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Acute Kidney Injury / prevention & control
Acute Lung Injury / prevention & control
Brain Injuries / prevention & control
Disease Models, Animal
Ischemic Preconditioning / methods*
Liver Diseases / prevention & control
Reperfusion Injury / prevention & control*
Grant Support
FS/06/023//British Heart Foundation; MC_G1002673//Medical Research Council; //Department of Health

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Ventricular septal rupture imaged with real-time three-dimensional transesophageal echocardiography:...
Next Document:  Indoor radon monitoring near an in situ leach mining site in D G Khan, Pakistan.