Document Detail


Protection of neutropenic mice from lethal Candida albicans infection by recombinant interleukin 1.
MedLine Citation:
PMID:  3261247     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Natural and synthetic immunomodulators that increase nonspecific resistance to infection are also known to induce interleukin 1 (IL 1) production. Previous studies have demonstrated a protective effect of recombinant human IL 1 beta against death from infection caused by Pseudomonas aeruginosa. In the present study we investigated the effect of IL 1 beta or IL 1 alpha on the survival of neutropenic mice with a lethal Candida albicans infection. Mice with cyclophosphamide-induced neutropenia were injected with 3 X 10(5) C. albicans i.v. When 80 ng IL 1 beta was given as a single i.p. injection 24 h before the infection, survival compared to that in control animals was as follows: 100% vs. 97% at 24 h, 83% vs. 70% at 48 h and 70% vs. 23% at 72 h after the infection (p less than 0.01). The effect of IL 1 was also apparent when it was given 1/2 h before or 6 h after the infection. The results obtained with 80 ng IL 1 alpha given at 24 h before infection were similar to that obtained with IL 1 beta. The numbers of Candida cultured from the blood, liver, spleen, and kidney were not significantly different in IL 1 beta-treated and control animals. Passive transfer of serum obtained from mice pretreated with IL 1 to recipient mice did not provide protection against a subsequent lethal candidal infection. In conclusion, the present study demonstrates that IL 1 beta and IL 1 alpha prolong survival in neutropenic mice with a lethal C. albicans infection.
Authors:
J W Van't Wout; J W Van der Meer; M Barza; C A Dinarello
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  European journal of immunology     Volume:  18     ISSN:  0014-2980     ISO Abbreviation:  Eur. J. Immunol.     Publication Date:  1988 Jul 
Date Detail:
Created Date:  1988-09-09     Completed Date:  1988-09-09     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  1273201     Medline TA:  Eur J Immunol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  1143-6     Citation Subset:  IM    
Affiliation:
Department of Infectious Diseases, University Hospital Leiden, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Agranulocytosis / physiopathology*
Animals
Candidiasis / microbiology,  prevention & control*
Female
Immunization, Passive
Interleukin-1 / therapeutic use*
Mice
Neutropenia / physiopathology*
Recombinant Proteins
Grant Support
ID/Acronym/Agency:
AI 15614/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Interleukin-1; 0/Recombinant Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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