Document Detail


Protection of melanoma cells against superoxide radicals by melanins.
MedLine Citation:
PMID:  2558119     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Human melanoma cells transplanted into immunocompetent mice by the 6-day subrenal capsule technique are characterized by high resistance against immunological attack. This resistance is suggested to be the consequence of scavenging of superoxide free radicals by melanin. Scavenging of superoxide radicals by the melanoma cells was clearly demonstrated using electron spin resonance techniques. From comparison with synthetic melanins it is concluded that the scavenger effect can be attributed mainly to low-molecular-mass melanins synthesized in the melanoma cells whereas high-molecular-mass melanins are practically ineffective.
Authors:
K Schwabe; G Lassmann; W Damerau; H Naundorf
Related Documents :
1094959 - Microcytotoxicity and serum blocking factors in malignant melanoma and halo nevus.
18441159 - Signet ring cells of stromal derivation in the uterine cervix secondary to cauterisatio...
21133849 - Parthenogenetic cell lines: an unstable equilibrium between pluripotency and malignant ...
899 - Endosymbiosis and cellular tolerance in the hawaiian soft coral sarcothelia edmondsoni ...
1497119 - Epithelioid and spindle-cell hemangioendothelioma of the spleen. report of a distinctiv...
20619689 - Clear cells in the atrioventricular valves of infants with severe human mucopolysacchar...
19737599 - Thyroid hormones and the control of cell proliferation or cell differentiation: paradox...
738279 - Complexity of polysomal polyadenylated rna in undifferentiated and differentiated neuro...
422679 - Analysis of the significance of a periodic, cell size-controlled doubling in rates of m...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of cancer research and clinical oncology     Volume:  115     ISSN:  0171-5216     ISO Abbreviation:  J. Cancer Res. Clin. Oncol.     Publication Date:  1989  
Date Detail:
Created Date:  1990-02-14     Completed Date:  1990-02-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7902060     Medline TA:  J Cancer Res Clin Oncol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  597-600     Citation Subset:  IM    
Affiliation:
Academy of Sciences of GDR, Central Institute for Cancer Research, Berlin-Buch.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Electron Spin Resonance Spectroscopy
Free Radicals
Humans
Melanins / pharmacology*
Melanoma / pathology*
Mice
Mice, Inbred C57BL
Neoplasm Transplantation
Superoxides / metabolism*
Tumor Cells, Cultured / drug effects*
Chemical
Reg. No./Substance:
0/Free Radicals; 0/Melanins; 11062-77-4/Superoxides

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Plasma glutamate levels, lymphocyte reactivity and death rate in patients with bronchial carcinoma.
Next Document:  Changes in nuclear distribution of large tumor antigen correlate with the proliferative activity of ...