Document Detail

Protection of melanoma cells against superoxide radicals by melanins.
MedLine Citation:
PMID:  2558119     Owner:  NLM     Status:  MEDLINE    
Human melanoma cells transplanted into immunocompetent mice by the 6-day subrenal capsule technique are characterized by high resistance against immunological attack. This resistance is suggested to be the consequence of scavenging of superoxide free radicals by melanin. Scavenging of superoxide radicals by the melanoma cells was clearly demonstrated using electron spin resonance techniques. From comparison with synthetic melanins it is concluded that the scavenger effect can be attributed mainly to low-molecular-mass melanins synthesized in the melanoma cells whereas high-molecular-mass melanins are practically ineffective.
K Schwabe; G Lassmann; W Damerau; H Naundorf
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of cancer research and clinical oncology     Volume:  115     ISSN:  0171-5216     ISO Abbreviation:  J. Cancer Res. Clin. Oncol.     Publication Date:  1989  
Date Detail:
Created Date:  1990-02-14     Completed Date:  1990-02-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7902060     Medline TA:  J Cancer Res Clin Oncol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  597-600     Citation Subset:  IM    
Academy of Sciences of GDR, Central Institute for Cancer Research, Berlin-Buch.
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MeSH Terms
Electron Spin Resonance Spectroscopy
Free Radicals
Melanins / pharmacology*
Melanoma / pathology*
Mice, Inbred C57BL
Neoplasm Transplantation
Superoxides / metabolism*
Tumor Cells, Cultured / drug effects*
Reg. No./Substance:
0/Free Radicals; 0/Melanins; 11062-77-4/Superoxides

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