Document Detail


Protection of the ischemic myocardium during the reperfusion: between hope and reality.
MedLine Citation:
PMID:  22937492     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
The heart is an organ that requires an important energy input to ensure its contractile function. Myocardial ischemia happens when there is a deficiency of blood flow that is responsible for the passage from an aerobic to anaerobic metabolism. Myocardial ischemia results from an imbalance between inputs and the needs of nutrient and oxygen to the myocardium. The restoration of myocardial perfusion called reperfusion is a way to save the ischemic myocardium. However, although reperfusion is beneficial for the survival of the ischemic myocardium, it also induces a deleterious effect in addition to that of ischemic stress. Three decade ago, while several studies, strived to elucidate the protective effect of preconditioning, a phenomenon performed before ischemia and having a powerful protective effects against ischemia/reperfusion injury, very few have believed in the possibility of protecting the myocardium after ischemia (during reperfusion). Actually, both ischemic and pharmacological postconditioning as well as controlled reperfusion methods to protect the ischemic heart have proved effective in the reduction of damage related to ischemia/reperfusion. The possibility of protecting the myocardium during reperfusion opens a new area in the research against damage caused by ischemia/reperfusion because these methods are easily transferable in a clinic setting.
Authors:
Jean Chrisostome Bopassa
Publication Detail:
Type:  Journal Article     Date:  2012-07-25
Journal Detail:
Title:  American journal of cardiovascular disease     Volume:  2     ISSN:  2160-200X     ISO Abbreviation:  Am J Cardiovasc Dis     Publication Date:  2012  
Date Detail:
Created Date:  2012-08-31     Completed Date:  2012-10-02     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  101569582     Medline TA:  Am J Cardiovasc Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  223-36     Citation Subset:  -    
Affiliation:
Division of Molecular Medicine, Department of Anesthesiology, David Geffen School of Medicine, University of California Los Angeles (UCLA) Los Angeles, CA 90095-1778, USA.
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