Document Detail


Protection of the gastric mucosa by linoleic acid--a nutrient essential fatty acid.
MedLine Citation:
PMID:  3621708     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We studied whether linoleic acid, a precursor for arachidonic acid and prostaglandins, could protect the gastric mucosa against ethanol-induced injury. Fasted male rats received intragastric pretreatment with 1 ml of one of: a) solubilizer; b) solubilized linoleic acid (74 mg); or c) solubilized oleic acid (74 mg) (a nonessential fatty acid). One hour later, 2 ml 100% ethanol was given intragastrically. Three hours after ethanol administration, the gastric mucosa was assessed for gross necrosis and for histologic changes. Three hours after ethanol administration in solubilizer, pretreated-group gross mucosal necrosis involved 35 +/- 3% of total mucosal area, while deep histologic necrosis involved 52 +/- 4% of the mucosal strip length. Pretreatment with linoleic acid (but not oleic acid) significantly reduced gross histologic necrosis, to 2.3 +/- 0.5%, and deep histologic necrosis to 4 +/- 2% (both p less than 0.001 versus solubilizer group). The protective action of linoleic acid was significantly reduced (greater than 10-fold) by pretreatment with indomethacin (prostaglandins synthetase inhibitor), suggesting prostaglandins as mediators of protection. The present study showed that effective protection of the gastric mucosa against ethanol injury can be achieved by intragastric administration of linoleic acid, a dietary essential fatty acid.
Authors:
A Tarnawski; D Hollander; H Gergely
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Clinical and investigative medicine. Médecine clinique et experimentale     Volume:  10     ISSN:  0147-958X     ISO Abbreviation:  Clin Invest Med     Publication Date:  1987 May 
Date Detail:
Created Date:  1987-10-20     Completed Date:  1987-10-20     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7804071     Medline TA:  Clin Invest Med     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  132-5     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Ethanol / administration & dosage,  adverse effects,  antagonists & inhibitors
Gastric Mucosa / drug effects*,  pathology
Linoleic Acid
Linoleic Acids / pharmacology*,  therapeutic use
Male
Necrosis / chemically induced,  prevention & control
Rats
Rats, Inbred Strains
Grant Support
ID/Acronym/Agency:
R01AM32865/AM/NIADDK NIH HHS
Chemical
Reg. No./Substance:
0/Linoleic Acids; 2197-37-7/Linoleic Acid; 64-17-5/Ethanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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