Document Detail

Protection of dogs for 13 months against Bordetella bronchiseptica and canine parainfluenza virus with a modified live vaccine.
MedLine Citation:
PMID:  15995238     Owner:  NLM     Status:  MEDLINE    
Twelve specific pathogen-free (spf) puppies were vaccinated intranasally with a bivalent, modified live vaccine against infectious tracheobronchitis (group 1) and six puppies of the same age and from the same source served as unvaccinated controls (group 2). Both groups were challenged with wild-type Bordetella bronchiseptica and canine parainfluenza virus by the aerosol route 56 weeks after group 1 had been vaccinated, and at the same time six 10-week-old spf puppies from the same source (group 3) were also challenged. Oronasal swabs were taken regularly before and after the challenge, for the isolation of bacteria and viruses, and the dogs were observed for clinical signs for three weeks after the challenge. The control dogs became culture-positive for B bronchiseptica and canine parainfluenza virus, but the isolation yields from the vaccinated group were significantly lower (P<0.05). The mean clinical scores of the vaccinated group were 61 per cent lower than the scores of group 2 (P=0.009), and 90 per cent lower than the scores of group 3 (P=0.001).
A A C Jacobs; R P H Theelen; R Jaspers; L J I Horspool; D Sutton; J G H E Bergman; G Paul
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Veterinary record     Volume:  157     ISSN:  0042-4900     ISO Abbreviation:  Vet. Rec.     Publication Date:  2005 Jul 
Date Detail:
Created Date:  2005-07-04     Completed Date:  2005-09-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0031164     Medline TA:  Vet Rec     Country:  England    
Other Details:
Languages:  eng     Pagination:  19-23     Citation Subset:  IM    
Intervet International, Wim de Körverstraat 35, PO Box 31, 5830 AA Boxmeer, The Netherlands.
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MeSH Terms
Antibodies, Viral / isolation & purification
Bordetella Infections / prevention & control,  veterinary*
Bordetella bronchiseptica / immunology*,  isolation & purification
Herpesviridae Infections / prevention & control,  veterinary*
Herpesvirus 1, Canid / immunology*,  pathogenicity
Parainfluenza Vaccines*
Paramyxoviridae Infections / prevention & control,  veterinary*
Vaccination / veterinary*
Viral Vaccines*
Reg. No./Substance:
0/Antibodies, Viral; 0/Parainfluenza Vaccines; 0/Viral Vaccines

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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