Document Detail

Protection of cultured mammalian cells by S-2-(3-aminopropylamino)ethylphosphorothioic acid(WR-2721).
MedLine Citation:
PMID:  6313559     Owner:  NLM     Status:  MEDLINE    
The ability of WR-2721 to protect cultured mammalian cells against radiation-induced killing was nearly the same as that of cysteamine when WR-2721 was activated by mouse liver extract. Without the liver extract, protection by WR-2721 required long incubations with the cells prior to irradiation. The protective activity increased in proportion to the cell concentration. The dose reduction factor at a concentration of 4 mM WR-2721 was 1.11 and 1.41 for 1.5 X 10(5) cells/ml and 15 X 10(5) cells/ml of cultured cells, respectively. A non-protein bound sulfhydryl group was detected in cell suspensions after incubation with WR-2721, but it was not a dephosphorylated product of WR-2721.
S Antoku
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  International journal of radiation oncology, biology, physics     Volume:  9     ISSN:  0360-3016     ISO Abbreviation:  Int. J. Radiat. Oncol. Biol. Phys.     Publication Date:  1983 Oct 
Date Detail:
Created Date:  1983-12-17     Completed Date:  1983-12-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7603616     Medline TA:  Int J Radiat Oncol Biol Phys     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1481-5     Citation Subset:  IM    
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MeSH Terms
Amifostine / therapeutic use*,  toxicity
Cells, Cultured
Cobalt Radioisotopes / therapeutic use
Cysteamine / therapeutic use
Dose-Response Relationship, Drug
Drug Evaluation, Preclinical
Leukemia L5178 / radiotherapy*
Leukemia, Experimental / radiotherapy*
Mercaptoethylamines / therapeutic use
Organothiophosphorus Compounds / therapeutic use*
Radiation-Protective Agents / therapeutic use
Time Factors
Tissue Extracts / therapeutic use
Reg. No./Substance:
0/Cobalt Radioisotopes; 0/Mercaptoethylamines; 0/Organothiophosphorus Compounds; 0/Radiation-Protective Agents; 0/Tissue Extracts; 20537-88-6/Amifostine; 31098-42-7/WR 1065; 60-23-1/Cysteamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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