| Protection of the chronic hypoxic immature rat heart during global ischemia. | |
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MedLine Citation:
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PMID: 7887715 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The benefit of cardioplegic cardiac arrest for the protection of immature myocardium is controversial. We therefore investigated the efficacy of (1) topical hypothermia alone, (2) slow cooling by coronary perfusion hypothermia, and (3) cardioplegic cardiac arrest for the protection of isolated immature rats hearts (28 days) during 8 hours of global ischemia at 10 degrees C. The study was conducted in hearts from rats that were kept hypoxemic by lifelong exposure to simulated high altitude. Left ventricular function, endothelial function, the metabolic status, and the extent of myocardial injury were all assessed. Topical hypothermia provided superior protection in hypoxic hearts, with recovery of the maximum developed left ventricular pressure by 70.6% +/- 18.0% (mean +/- standard deviation) of its preischemic value (p < 0.01 versus slow cooling and versus cardioplegic protection). The same pattern of recovery was observed among control hearts. The degree of recovery of endothelial function after sole topical hypothermia measured 54% +/- 36% in hypoxic hearts and 62% +/- 37% in control hearts, but was not recordable in any of the other groups. Creatine kinase leakage and the myocardial high-energy content did not differ significantly among any of the groups. Rapid cooling by topical hypothermia alone provides superior protection in chronic hypoxic, immature rat hearts versus the protection conferred by slow cooling. St. Thomas' Hospital cardioplegic solution II does not afford additional protection. Endothelial injury caused by cold asanguineous perfusates, including cardioplegia, interferes with the recovery of vascular function, which, in turn, may limit mechanical function. |
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Authors:
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M Karck; G Ziemer; M Zoeller; S Schulte; K D Juergens; H Weisser; A Haverich |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Annals of thoracic surgery Volume: 59 ISSN: 0003-4975 ISO Abbreviation: Ann. Thorac. Surg. Publication Date: 1995 Mar |
Date Detail:
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Created Date: 1995-04-07 Completed Date: 1995-04-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 15030100R Medline TA: Ann Thorac Surg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 699-706 Citation Subset: AIM; IM |
Affiliation:
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Department of Cardiovascular Surgery, University of Kiel, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine Triphosphate
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metabolism Animals Bicarbonates / pharmacology Blood Gas Analysis Calcium Chloride / pharmacology Cardioplegic Solutions / pharmacology Cell Hypoxia Chronic Disease Creatine Kinase / metabolism Endothelium, Vascular Fetal Heart / drug effects, metabolism, physiopathology Heart Arrest, Induced / methods* Heart Function Tests Hypothermia, Induced Magnesium / pharmacology Male Myocardial Ischemia / etiology, metabolism, physiopathology, prevention & control* Myocardial Reperfusion Injury / etiology, metabolism, physiopathology, prevention & control* Oxygen Consumption Phosphocreatine / metabolism Potassium Chloride / pharmacology Rats Rats, Wistar Sodium Chloride / pharmacology Time Factors Ventricular Function, Left |
| Chemical | |
Reg. No./Substance:
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0/Bicarbonates; 0/Cardioplegic Solutions; 0/St. Thomas' Hospital cardioplegic solution; 10043-52-4/Calcium Chloride; 56-65-5/Adenosine Triphosphate; 67-07-2/Phosphocreatine; 7439-95-4/Magnesium; 7447-40-7/Potassium Chloride; 7647-14-5/Sodium Chloride; EC 2.7.3.2/Creatine Kinase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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