Document Detail

Protection by carbocromene and molsidomine against arrhythmias occurring during coronary artery occlusion and reperfusion in dogs.
MedLine Citation:
PMID:  2413309     Owner:  NLM     Status:  MEDLINE    
We studied the effects of carbocromene (4 mg/kg plus 40 micrograms/kg/min i.v.) and molsidomine (0.1 mg/kg plus 2 micrograms/kg/min i.v.) on arrhythmias occurring during 90-min occlusion and 30-min reperfusion of the left anterior descending coronary artery in anesthetized dogs. Both drugs reduced the incidence of left ventricular (LV) premature depolarization during ligation (39% after carbocromene and 33% after molsidomine vs. 80% in controls; both p less than 0.05) and tachycardia (44% after carbocromene and 38% after molsidomine vs. 85% in controls; p less than 0.05). During reperfusion, the incidence of LV fibrillation was reduced in the carbocromene- (6 vs. 38% in controls; p less than 0.05) and molsidomine-treated dogs (10 vs. 38% in controls; p less than 0.05). The high incidence of ectopic activity and the ST segment elevation occurring after coronary ligation in control animals were prevented by both drugs. The hemodynamic deterioration after coronary occlusion, i.e., increase in blood pressure, LV systolic and end-diastolic pressures, LV dP/dtmax, and tachycardia observed in controls, was prevented by carbocromene. Molsidomine reduced blood pressure and LV pressure by 18 and 27% (p less than 0.05), respectively, during coronary occlusion. During reperfusion, no hemodynamic alterations occurred in the drug-treated animals. We conclude that carbocromene reduced the electrophysiologic consequences of acute ischemia by hemodynamic and anti-ischemic effects on heart metabolism. Molsidomine protected the jeopardized heart by a similar attenuation of hemodynamic derangement after coronary occlusion and perhaps by influencing prostanoid release from the ischemic myocardium.
V B Fiedler; B Kettenbach; H Göbel; R E Nitz
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  7     ISSN:  0160-2446     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:    1985 Sep-Oct
Date Detail:
Created Date:  1985-11-21     Completed Date:  1985-11-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  964-70     Citation Subset:  IM    
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MeSH Terms
Arrhythmias, Cardiac / etiology,  prevention & control*
Arterial Occlusive Diseases / complications
Chromonar / therapeutic use*
Coronary Vessels / physiopathology*
Coumarins / therapeutic use*
Oxadiazoles / therapeutic use*
Sydnones / therapeutic use*
Time Factors
Vasodilator Agents / therapeutic use*
Reg. No./Substance:
0/Coumarins; 0/Oxadiazoles; 0/Sydnones; 0/Vasodilator Agents; 25717-80-0/Molsidomine; 804-10-4/Chromonar

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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