Document Detail


Protection by carbocromene and molsidomine against arrhythmias occurring during coronary artery occlusion and reperfusion in dogs.
MedLine Citation:
PMID:  2413309     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We studied the effects of carbocromene (4 mg/kg plus 40 micrograms/kg/min i.v.) and molsidomine (0.1 mg/kg plus 2 micrograms/kg/min i.v.) on arrhythmias occurring during 90-min occlusion and 30-min reperfusion of the left anterior descending coronary artery in anesthetized dogs. Both drugs reduced the incidence of left ventricular (LV) premature depolarization during ligation (39% after carbocromene and 33% after molsidomine vs. 80% in controls; both p less than 0.05) and tachycardia (44% after carbocromene and 38% after molsidomine vs. 85% in controls; p less than 0.05). During reperfusion, the incidence of LV fibrillation was reduced in the carbocromene- (6 vs. 38% in controls; p less than 0.05) and molsidomine-treated dogs (10 vs. 38% in controls; p less than 0.05). The high incidence of ectopic activity and the ST segment elevation occurring after coronary ligation in control animals were prevented by both drugs. The hemodynamic deterioration after coronary occlusion, i.e., increase in blood pressure, LV systolic and end-diastolic pressures, LV dP/dtmax, and tachycardia observed in controls, was prevented by carbocromene. Molsidomine reduced blood pressure and LV pressure by 18 and 27% (p less than 0.05), respectively, during coronary occlusion. During reperfusion, no hemodynamic alterations occurred in the drug-treated animals. We conclude that carbocromene reduced the electrophysiologic consequences of acute ischemia by hemodynamic and anti-ischemic effects on heart metabolism. Molsidomine protected the jeopardized heart by a similar attenuation of hemodynamic derangement after coronary occlusion and perhaps by influencing prostanoid release from the ischemic myocardium.
Authors:
V B Fiedler; B Kettenbach; H Göbel; R E Nitz
Related Documents :
3337389 - Effects of halothane, enflurane, and isoflurane on coronary blood flow autoregulation a...
8125889 - Exercise training alters myogenic responses in porcine coronary resistance arteries.
10900179 - Hyperlipidemia with hypoglycemia reduces myocardial oxygen utilization efficiency but n...
23965159 - Regional variation in distal esophagus distensibility assessed using the functional lum...
1374299 - Nitric oxide modulates coronary autoregulation in the guinea pig.
1121509 - Direct effects of hypoosmolality on vascular resistance and myocardial contractile forc...
16436889 - Predicted hemodynamic benefits of counterpulsation therapy using a superficial surgical...
23099889 - L-carnitine and long-chain acylcarnitines are positively correlated with ambulatory blo...
1415639 - Interactions of physiological and pharmacological concentrations of anp and angiotensin...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  7     ISSN:  0160-2446     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:    1985 Sep-Oct
Date Detail:
Created Date:  1985-11-21     Completed Date:  1985-11-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  964-70     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Anesthesia
Animals
Arrhythmias, Cardiac / etiology,  prevention & control*
Arterial Occlusive Diseases / complications
Chromonar / therapeutic use*
Coronary Vessels / physiopathology*
Coumarins / therapeutic use*
Dogs
Electrocardiography
Female
Male
Molsidomine
Oxadiazoles / therapeutic use*
Perfusion
Sydnones / therapeutic use*
Time Factors
Vasodilator Agents / therapeutic use*
Chemical
Reg. No./Substance:
0/Coumarins; 0/Oxadiazoles; 0/Sydnones; 0/Vasodilator Agents; 25717-80-0/Molsidomine; 804-10-4/Chromonar

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Antagonism of vasopressin-induced coronary artery constriction by the vasopressin antagonist d(CH2)5...
Next Document:  Effects of prostacyclin on contractile properties of isolated mammalian cardiac muscle.